{"102391":{"#nid":"102391","#data":{"type":"news","title":"Understanding the Role of Sphingolipids in Cancer Development","body":[{"value":"\u003Cp\u003E\u003Ca href=\u0022http:\/\/gtresearchnews.gatech.edu\/\u0022\u003EResearch Horizons\u003C\/a\u003E, July 09 - For almost 30 years, Georgia Tech professor Alfred Merrill has been studying lipids - the fats, oils, cholesterols and certain vitamins that our bodies need to grow and survive. Today, his expertise lies in a subgroup of lipids called sphingolipids, which influence cell structure, \u003C\/p\u003E\n\u003Cp\u003E\u0022The lipid backbones of sphingolipids are important cell-signaling molecules that turn on and turn off intracellular proteins that are involved in cell growth, death, and an interesting process called autophagy that has recently gained much attention in the cancer research field,\u0022 says Merrill, who is also the School of Biology\u0027s Smithgall Chair in Molecular Cell Biology.\n\u003C\/p\u003E\n\u003Cp\u003EAutophagy - meaning \u0022self-eating\u0022 - involves the degradation of cellular compartments, called organelles, and cellular proteins. During this process, a cell forms a vesicle that encapsulates its cytoplasm and some of the organelles and then fuses with digestive enzymes that degrade the contents of the vesicle and make them available for cell nutrition.\n\u003C\/p\u003E\n\u003Cp\u003EInterestingly, autophagy has been implicated in both cancer cell death and survival. Since Merrill\u0027s research has shown that sphingolipid signaling is essential for creating autophagy vesicles, these metabolites may be involved in both promoting and limiting tumor growth.\n\u003C\/p\u003E\n\u003Cp\u003EAutophagy promotes cancer cell survival by allowing cells to respond to changing environmental conditions, such as nutrient deprivation. During starvation, autophagy allows cells to degrade proteins and organelles and thus obtain a source of nutrients that would not be available otherwise.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022Cancer cells use autophagy because as they are developing they have a period in which they go into a nutrient crisis because they haven\u0027t established their own blood and nutrient flow, so they use autophagy as a way to survive in the meantime,\u0022 explains Merrill.\n\u003C\/p\u003E\n\u003Cp\u003EHowever, this same process of gaining nutrients can lead to tumor cell death as well. Merrill\u0027s laboratory found that a number of anti-cancer agents promote the formation of these vesicles through sphingolipid signaling.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022Preliminary data supports the theory that the autophagic vesicles in cancer cells are unstable, so if one of their components-the sphingolipids-is out of balance, this can cause them to break apart and spill out their toxic contents, killing the cancer cell,\u0022 adds Merrill.\n\u003C\/p\u003E\n\u003Cp\u003EWhile the mechanism through which autophagy inhibits tumor development is still unclear, graduate student Kacee Sims is examining the role of sphingolipid pathways in the conversion of autophagy from a cancer cell survival pathway to a cell death pathway.\n\u003C\/p\u003E\n\u003Cp\u003EThe project described was supported by Award No. U54GM069338 from the National Institute of General Medicine Sciences (NIGMS). Any opinions, findings, conclusions or recommendations expressed are those of the researcher and do not necessarily reflect the views of the NIGMS or the National Institutes of Health. Significant funding to support this research was also provided by the Smithgall Endowment Georgia Tech.\n\u003C\/p\u003E\n\u003Cp\u003EBy Abby Vogel\u003Cbr \/\u003E\nPhoto By Gary Meek\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Research Horizons - For almost 30 years, Georgia Tech professor Alfred Merrill has been studying lipids - the fats, oils, cholesterols and certain vitamins that our bodies need to grow and survive. Today, his expertise lies in a subgroup of lipids called sphingolipids, which influence cell structure, signaling and interaction.","format":"limited_html"}],"field_summary_sentence":[{"value":"Understanding the Role of Sphingolipids in Cancer Development"}],"uid":"27245","created_gmt":"2009-08-13 00:00:00","changed_gmt":"2016-10-08 03:11:13","author":"Troy Hilley","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2009-08-13T00:00:00-04:00","iso_date":"2009-08-13T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"102401":{"id":"102401","type":"image","title":"Al Merrill :: Photo By Gary Meek","body":null,"created":"1449178174","gmt_created":"2015-12-03 21:29:34","changed":"1475894723","gmt_changed":"2016-10-08 02:45:23"}},"media_ids":["102401"],"related_links":[{"url":"http:\/\/gtresearchnews.gatech.edu\/reshor\/rh-ws09\/cancer.pdf","title":"Research Horizon Article"},{"url":"http:\/\/gtresearchnews.gatech.edu\/","title":"Research Horizon"},{"url":"http:\/\/www.biology.gatech.edu\/faculty\/al-merrill\/","title":"Al Merrill"},{"url":"http:\/\/www.biology.gatech.edu\/","title":"School of Biology"}],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003ESchool of Biology\u003C\/strong\u003E\u003Cbr \/\u003EBiology\u003Cbr \/\u003E\u003Ca href=\u0022mailto:admin@biology.gatech.edu\u0022\u003EContact School of Biology\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-3700\u003C\/strong\u003E","format":"limited_html"}],"email":["admin@biology.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}