{"138561":{"#nid":"138561","#data":{"type":"news","title":"New Technique to Improve Blood Flow in Children Born with one Functional Ventricle Shows Promise","body":[{"value":"\u003Cp\u003ETwo in every thousand babies born in the United States start life with just one functional ventricle, or pumping chamber, instead of the normal two. These babies typically undergo a series of two or three open-heart surgeries, culminating in a \u201ctotal cavopulmonary connection\u201d (TCPC), which is known as the Fontan procedure. During this process, surgeons redirect the circulation to allow oxygen-poor blood to flow from the body directly to the lungs passively, without the benefit of a pumping chamber.\u003C\/p\u003E\u003Cp\u003EA team of surgeons and university researchers recently reported promising results from a novel surgical connection intended to streamline blood flow between the heart and lungs of such infants.\u003C\/p\u003E\u003Cp\u003ETypically, the final stage of the Fontan procedure is performed by connecting a cylindrical conduit to the pulmonary arteries, forming a \u2018T\u2019 shaped junction. In a pilot study, six patients at Children\u2019s Healthcare of Atlanta received a commercially available Y-shaped conduit for their Fontan procedure instead of the cylindrical conduit to create a smoother transition of the blood flow to the pulmonary arteries. Postoperative imaging data from the patients indicated improved blood flow distribution and similar energy efficiency when compared with computer simulations of two alternative connections the patients could have received instead of a Y-graft.\u003C\/p\u003E\u003Cp\u003E\u201cBased on improved energy characteristics predicted by computer modeling for the Y-shaped conduit, we felt it was time to try it in the clinical realm,\u201d said Kirk Kanter, M.D., chief of cardiothoracic surgery at Children\u2019s Healthcare of Atlanta and professor of surgery at Emory University School of Medicine, who performed the operations. \u201cThe pilot study revealed that surgical implementation of a Y-graft for Fontan procedures is feasible and promising because early outcome was good in these patients.\u201d\u003C\/p\u003E\u003Cp\u003EThe surgical procedure and the postoperative outcomes were detailed in two articles recently published online in the\u0026nbsp;\u003Cem\u003EJournal of Thoracic and Cardiovascular Surgery\u0026nbsp;\u003C\/em\u003E(articles available\u0026nbsp;\u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.jtcvs.2012.05.015\u0022 target=\u0022_blank\u0022\u003Ehere\u003C\/a\u003E\u0026nbsp;and\u0026nbsp;\u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.jtcvs.2012.03.076\u0022 target=\u0022_blank\u0022\u003Ehere\u003C\/a\u003E). The research was funded by the National Institutes of Health and the American Heart Association.\u003C\/p\u003E\u003Cp\u003EAlso involved in the study were\u0026nbsp;\u003Ca href=\u0022http:\/\/www.bme.gatech.edu\/facultystaff\/faculty_record.php?id=5\u0022 target=\u0022_blank\u0022\u003EAjit Yoganathan\u003C\/a\u003E, Ph.D., Regents\u2019 professor in the\u0026nbsp;\u003Ca href=\u0022http:\/\/www.bme.gatech.edu\u0022 target=\u0022_blank\u0022\u003EWallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University\u003C\/a\u003E; W. James Parks, M.D., associate professor of pediatrics and radiology at Emory University and Children\u2019s Healthcare of Atlanta at Egleston; Mark A. Fogel, M.D., director of cardiac magnetic resonance at The Children\u2019s Hospital of Philadelphia;\u0026nbsp;\u003Ca href=\u0022http:\/\/www.ic.gatech.edu\u0022 target=\u0022_blank\u0022\u003EGeorgia Tech School of Interactive Computing\u003C\/a\u003E\u0026nbsp;Professor\u0026nbsp;\u003Ca href=\u0022http:\/\/www.ic.gatech.edu\/people\/jarek-rossignac\u0022 target=\u0022_blank\u0022\u003EJarek Rossignac\u003C\/a\u003E, Ph.D., and Coulter Department graduate student Christopher Haggerty.\u003C\/p\u003E\u003Cp\u003EThe TCPC typically creates a four-way intersection. Blood from the upper half of the body enters the intersection from the top and blood from the lower body enters from the bottom. The blood flows collide and mix in the intersection before they are split and redirected 90 degrees toward the left or right pulmonary arteries. The collision of blood from the two veins at the intersection causes inefficient blood flow.\u003C\/p\u003E\u003Cp\u003EBecause the blood flows passively from the body to the lungs without being pumped by the heart, it is assumed that any energy inefficiencies inherent in the construction of the Fontan pathway may translate into diminished life expectancy and quality of life.\u003C\/p\u003E\u003Cp\u003ESubstituting a Y-shaped conduit should avoid the collision of blood in the intersection and enable a smooth and streamlined transition of the blood to the pulmonary arteries, which carry deoxygenated blood from the heart to the lungs.\u003C\/p\u003E\u003Cp\u003EFor the pilot study, Kanter surgically implanted a commercially available Y-graft, made of a synthetic polymer called polytetrafluoroethylene, in each patient to direct flow from the lower half of the body to the left and right pulmonary arteries. This was a variation of a conduit design, called the Optiflo, which was patented by Yoganathan and colleagues for its ability to efficiently direct an even distribution of blood flow to the left and right pulmonary arteries.\u003C\/p\u003E\u003Cp\u003EAfter surgery, the researchers acquired magnetic resonance or computed tomography images to evaluate the operative connections. The images allowed Yoganathan and Haggerty to evaluate the hemodynamic outcomes of the surgical procedures for five of the six patients and compare them to the simulated outcomes of two alternative connections the patients could have received instead of a Y-graft.\u003C\/p\u003E\u003Cp\u003EThey used the images to model blood flow through the arteries under resting and exercise conditions. These simulations assessed the robustness of each connection geometry because small inefficiencies under resting conditions may be amplified with higher flows.\u003C\/p\u003E\u003Cp\u003EResults for the patients who received the Y-graft showed balanced distribution of flow to both pulmonary arteries with minimal flow disturbance. The resistance of the vessels to blood flow at the connections varied considerably among patients, but the Y-graft results demonstrated resistance levels similar to the alternative connections in four patients and marked improvement in a fifth patient.\u003C\/p\u003E\u003Cp\u003E\u201cWe found desirable flow distribution characteristics using the Y-graft, but the flow efficiency performance fell short of the outcomes we previously predicted,\u201d said Yoganathan. \u201cThe results suggest that the Y-graft performs as well as the standard procedure with a T-graft even when the Y-graft design is theoretically sub-optimal.\u201d\u003C\/p\u003E\u003Cp\u003EThe study allowed the researchers to identify ways of refining the surgical technique that should help them improve the theoretical efficiency of the conduit design. Before conducting future clinical trials, the research team plans to address two features of the Y-graft design that limited hemodynamic efficiency in the current study. They plan to introduce curvature to the Y-graft branches and extend the distance between the Y-graft branches to reduce continued interaction and mixing between the two blood streams.\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EResearch reported in this publication was supported by the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH) under award numbers HL67622 and HL098252 and by a Pre-Doctoral Fellowship Award from the American Heart Association (AHA) (10PRE372002). The content is solely the responsibility of the principal investigators and does not necessarily represent the official views of the NIH.\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EResearch News \u0026amp; Publications Office\u003Cbr \/\u003E Georgia Institute of Technology\u003Cbr \/\u003E 75 Fifth Street, N.W., Suite 314\u003Cbr \/\u003E Atlanta, Georgia 30308 USA\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMedia Relations Contacts:\u003C\/strong\u003E Abby Robinson (abby@innovate.gatech.edu; 404-385-3364) or John Toon (jtoon@gatech.edu; 404-894-6986)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EWriter: \u003C\/strong\u003EAbby Robinson\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EA team of surgeons and university researchers recently reported promising results from a novel surgical connection intended to streamline blood flow between the heart and lungs of infants born with just one functional ventricle, or pumping chamber, instead of the normal two.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"A team of surgeons and university researchers recently reported promising results from a novel surgical connection intended to streamline blood flow between the heart and lungs of infants born with just one functional ventricle, or pumping chamber, i"}],"uid":"27206","created_gmt":"2012-07-03 08:46:13","changed_gmt":"2016-10-08 03:12:29","author":"Abby Vogel Robinson","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2012-07-03T00:00:00-04:00","iso_date":"2012-07-03T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"138691":{"id":"138691","type":"image","title":"Fontan procedure Y-graft","body":null,"created":"1449178698","gmt_created":"2015-12-03 21:38:18","changed":"1475894769","gmt_changed":"2016-10-08 02:46:09","alt":"Fontan procedure Y-graft","file":{"fid":"194883","name":"fontan_image.jpg","image_path":"\/sites\/default\/files\/images\/fontan_image_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/fontan_image_0.jpg","mime":"image\/jpeg","size":191866,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/fontan_image_0.jpg?itok=5RRib9l9"}}},"media_ids":["138691"],"groups":[{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"145","name":"Engineering"},{"id":"135","name":"Research"}],"keywords":[{"id":"2582","name":"Ajit Yoganathan"},{"id":"1440","name":"blood"},{"id":"37591","name":"blood flow"},{"id":"7104","name":"cardiovascular"},{"id":"9721","name":"Children\u0027s Healthcare of Atlanta"},{"id":"654","name":"College of Computing"},{"id":"594","name":"college of engineering"},{"id":"11533","name":"Department of Biomedical Engineering"},{"id":"2586","name":"Fontan"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EAbby Robinson\u003Cbr \/\u003E Research News and Publications\u003Cbr \/\u003E \u003Ca href=\u0022mailto:abby@innovate.gatech.edu\u0022\u003Eabby@innovate.gatech.edu\u003C\/a\u003E\u003Cbr \/\u003E 404-385-3364\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}