{"146631":{"#nid":"146631","#data":{"type":"event","title":"Prof. Paloma Giangrande, University of Iowa","body":[{"value":"\u003Cp\u003EProf. Paloma Giangrande, University of Iowa\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003ETIGRs: Targeted image-guided RNA therapies\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EBiochemistry Division Seminar Series\u003C\/p\u003E\u003Cp\u003EDr. Giangrande \u0027s research interests include developing RNA-based therapeutics to modulate cellular pathways underlying pathological cell proliferation in the setting of cancer and cardiovascular disease.\u0026nbsp; One area of Dr. Giangrande\u2019s lab focuses on selecting RNA aptamers to receptors expressed on the surface of target-cells with SELEX (Systemic Evolution of Ligands by EXponential Enrichment) for the purpose of 1) modulating receptor function and\/or 2) delivering therapeutic molecules (e.g. siRNAs, antagomirs, drugs) into specific cell types.\u0026nbsp; A second interest of the Giangrande lab is to use genomic\/proteomic methodologies to acquire important insights into the mechanisms of pathological cell proliferation.\u0026nbsp; In addition to providing useful mechanistic information, this knowledge will be used to identify novel membrane proteins that can be targeted with therapeutic RNAs for treating cancer or pathological vascular hyperplasia.\u003C\/p\u003E\u003Cp\u003EFor more information contact Prof. M. G. Finn (404-894-0591)\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EProf. Paloma Giangrande, University of Iowa\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003ETIGRs: Targeted image-guided RNA therapies\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EBiochemistry Division Seminar Series\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Paloma Giangrande, University of Iowa"}],"uid":"27275","created_gmt":"2012-08-16 09:17:39","changed_gmt":"2016-10-08 01:59:28","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2013-04-02T17:00:00-04:00","event_time_end":"2013-04-02T18:00:00-04:00","event_time_end_last":"2013-04-02T18:00:00-04:00","gmt_time_start":"2013-04-02 21:00:00","gmt_time_end":"2013-04-02 22:00:00","gmt_time_end_last":"2013-04-02 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.int-med.uiowa.edu\/divisions\/hemonc\/Directory\/PalomaGiangrande.html","title":"Prof. Paloma Giangrande"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShirley Tomes (404-894-0591) \u003Ca href=\u0022mailto:shirley.tomes@chemistry.gatech.edu\u0022\u003Eshirley.tomes@chemistry.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}