{"154481":{"#nid":"154481","#data":{"type":"event","title":"Prof. Massimiliano Di Ventra, University of California San Diego","body":[{"value":"\u003Cp\u003EProf. Massimiliano Di Ventra, University of California San Diego\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EProbing DNA in nanopores via tunneling: From sequencing to \u0022quantum\u0022 analogies\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ESchool Colloquium\u003C\/p\u003E\u003Cp\u003EFast and low-cost DNA sequencing methods would revolutionize medicine: a person could have his\/her full genome sequenced so that drugs could be tailored to his\/her specific illnesses; doctors could know in advance patients\u2019 likelihood to develop a given ailment; cures to major diseases could be found faster [1]. However, this goal of \u201cpersonalized medicine\u201d is hampered today by the high cost and slow speed of DNA sequencing methods. In this talk, I will discuss the sequencing protocol we suggest which requires the measurement of the distributions of transverse currents during the translocation of single-stranded DNA into nanopores [2-5]. I will support our conclusions with a combination of molecular dynamics simulations coupled to quantum mechanical calculations of electrical current in experimentally realizable systems [2-5]. I will also discuss recent experiments that support these theoretical predictions. In addition, I will show how this relatively unexplored area of research at the interface between solids, liquids, and biomolecules at the nanometer length scale is a fertile ground to study quantum phenomena that have a classical counterpart, such as ionic quasi-particles, ionic \u201cquantized\u201d conductance [6,7] and Coulomb blockade [8].\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E[1] M. Zwolak, M. Di Ventra, \u003Ca href=\u0022http:\/\/physics.ucsd.edu\/%7Ediventra\/DNAreviewfinal.pdf\u0022\u003E\u003Cem\u003EPhysical Approaches to DNA Sequencing and Detection\u003C\/em\u003E, \u003C\/a\u003ERev. Mod. Phys. \u003Cstrong\u003E80\u003C\/strong\u003E, 141 (2008).\u003C\/p\u003E\u003Cp\u003E[2] M. Zwolak and M. Di Ventra, \u003Cem\u003EElectronic signature of DNA nucleotides via transverse transport\u003C\/em\u003E, Nano Lett. \u003Cstrong\u003E5\u003C\/strong\u003E, 421 (2005).\u003C\/p\u003E\u003Cp\u003E[3] J. Lagerqvist, M. Zwolak, and M. Di Ventra, \u003Cem\u003EFast DNA sequencing via transverse electronic transport\u003C\/em\u003E, Nano Lett. \u003Cstrong\u003E6\u003C\/strong\u003E, 779 (2006).\u003C\/p\u003E\u003Cp\u003E[4] J. Lagerqvist, M. Zwolak, and M. Di Ventra, \u003Cem\u003EInfluence of the environment and probes on rapid DNA sequencing via transverse electronic transport\u003C\/em\u003E, Biophys. J. \u003Cstrong\u003E93\u003C\/strong\u003E, 2384 (2007).\u003C\/p\u003E\u003Cp\u003E[5] M. Krems, M. Zwolak, Y.V. Pershin, and M. Di Ventra, \u003Cem\u003EEffect of noise on DNA sequencing via transverse electronic transport\u003C\/em\u003E, Biophys. J. \u003Cstrong\u003E97\u003C\/strong\u003E, 1990, (2009).\u003C\/p\u003E\u003Cp\u003E[6] M. Zwolak, J. Lagerqvist, and M. Di Ventra, \u003Cem\u003EIonic conductance quantization in nanopores,\u003C\/em\u003E Phys. Rev.Lett. \u003Cstrong\u003E103\u003C\/strong\u003E, 128102 (2009).\u003C\/p\u003E\u003Cp\u003E[7] M. Zwolak, J. Wilson, and M. Di Ventra, \u003Cem\u003EDehydration and ionic conductance quantization in nanopores\u003C\/em\u003E, J. Phys. Cond. Matt. \u003Cstrong\u003E22\u003C\/strong\u003E 454126 (2011).\u003C\/p\u003E\u003Cp\u003E[8] M. Krems and M. Di Ventra, \u003Cem\u003EIonic Coulomb blockade in nanopores\u003C\/em\u003E arXiv:1103.2749.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EProf. Massimiliano Di Ventra, University of California San Diego\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EProbing DNA in nanopores via tunneling: From sequencing to \u0022quantum\u0022 analogies\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ESchool Colloquium\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Massimiliano Di Ventra, University of California San Diego"}],"uid":"27275","created_gmt":"2012-09-17 09:08:42","changed_gmt":"2016-10-08 01:59:57","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-10-25T17:00:00-04:00","event_time_end":"2012-10-25T18:00:00-04:00","event_time_end_last":"2012-10-25T18:00:00-04:00","gmt_time_start":"2012-10-25 21:00:00","gmt_time_end":"2012-10-25 22:00:00","gmt_time_end_last":"2012-10-25 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/physics.ucsd.edu\/~diventra\/","title":"Prof. Massimo Di Ventra"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShirley Tomes (404-894-0591) \u003Ca href=\u0022mailto:shirley.tomes@chemistry.gatech.edu\u0022\u003Eshirley.tomes@chemistry.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}