{"162811":{"#nid":"162811","#data":{"type":"event","title":"Zheng \u0022John\u0022 Qu - Ph.D. Defense","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E:\u0026nbsp; Elliot L. Chaikof, M.D., Ph.D. (Harvard Medical School)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003Cbr \/\u003ELarry V. McIntire, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003EJulia E. Babensee, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003EW. Robert Taylor, M.D., Ph.D. (Emory University School of Medicine)\u003Cbr \/\u003EStephen R. Hanson, Ph.D. (Oregon Health and Science University)\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E\u003Cp\u003EAll artificial organ systems and medical devices that operate in direct contact with blood elicit activation of coagulation and platelets, and their long-term use often necessitates antithrombotic therapies that carry significant cost and bleeding risk.\u0026nbsp; Thrombomodulin (TM) is a major endogenous inhibitor of blood coagulation localized on the endothelial cell surface.\u0026nbsp; The overall objective of this research is to develop clinically durable synthetic materials by incorporating TM as a solid-supported film to actively and sustainably attenuate thrombus formation at the blood-contacting interface.\u003C\/p\u003E\u003Cp\u003EDuring the course of this research, we developed site-specific approaches to covalently attach TM on the luminal surface of commercial vascular grafts using bioorthogonal chemistry that was compatible with ethylene oxide sterilization.\u0026nbsp; Notably, we demonstrated the superior efficacy of TM to reduce platelet deposition compared with commercial heparin modified grafts using a non-human primate model of acute graft thrombosis.\u0026nbsp; Finally, we optimized a novel reversible chemistry to rapidly and repeatedly regenerate immobilized TM, with the potential to significantly extend the lifetime of biologically active films.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u201cBiologically Active Assemblies That Attenuate Thrombosis on Blood-Contacting Surfaces\u201d\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Biologically Active Assemblies That Attenuate Thrombosis on Blood-Contacting Surfaces"}],"uid":"27547","created_gmt":"2012-10-17 09:38:53","changed_gmt":"2016-10-08 02:00:42","author":"Chris Ruffin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-10-30T16:00:00-04:00","event_time_end":"2012-10-30T18:00:00-04:00","event_time_end_last":"2012-10-30T18:00:00-04:00","gmt_time_start":"2012-10-30 20:00:00","gmt_time_end":"2012-10-30 22:00:00","gmt_time_end_last":"2012-10-30 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:chris.ruffin@ibb.gatech.edu\u0022\u003EMr. Chris Ruffin\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}