{"170251":{"#nid":"170251","#data":{"type":"event","title":"Immunophysics of Host-pathogen Interactions: An Immune-cell Perspective","body":[{"value":"\u003Ch3\u003E\u003Cstrong\u003ESchool of Physics Soft Condensed Matter and Biophysics Seminar: Presenting Volkmar Heinrich, University of California, Davis\u003C\/strong\u003E\u003C\/h3\u003E\u003Cp\u003EMotile immune cells like neutrophils (the most abundant type of white blood cell) track down invading microbes by chemotaxis, keep hold of them by adhesion, and neutralize them by phagocytosis.\u0026nbsp; We integrate concepts and tools from immunobiology and biophysics to examine the mechanistic underpinnings of this amazing, cross-disciplinary feat.\u0026nbsp; Single-live-cell experiments using micropipette manipulation, optical tweezers, and a new type of horizontal atomic force microscope allow us to assess the nano-to-microscale ingredients of one-on-one encounters between human neutrophils and their targets (such as opsonized particles or pathogenic fungi and bacteria).\u0026nbsp; We dissect such encounters by examining separately the immunophysical roles of opsonization, chemotaxis, immune-cell priming, adhesion, and phagocytosis, as well as their vital interplay.\u0026nbsp; Providing a fresh view of the initiation of host-pathogen interactions, this approach demonstrates how the integration of essential physical insight with immunobiology allows us to define tighter constraints on possible explanations of cell and molecular behavior.\u0026nbsp; \u003C\/p\u003E\u003Cp\u003ER\u003Cstrong\u003Eeference:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EHeinrich, V., and C.-Y. Lee.\u0026nbsp; (2011).\u0026nbsp; Blurred line between chemotactic chase and phagocytic consumption:\u0026nbsp; An immunophysical, single-cell perspective.\u0026nbsp; \u003Cem\u003E\u003Cstrong\u003EJournal of Cell Science\u003C\/strong\u003E\u003C\/em\u003E\u0026nbsp; 124(18):3041-3051.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Ch2 class=\u0022mainTitle\u0022\u003EImmunophysics of host-pathogen interactions: An immune-cell perspective\u003C\/h2\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Immunophysics of host-pathogen interactions: An immune-cell perspective"}],"uid":"27664","created_gmt":"2012-11-12 10:59:23","changed_gmt":"2016-10-08 02:01:11","author":"Alison Morain","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-11-13T14:00:00-05:00","event_time_end":"2012-11-13T15:00:00-05:00","event_time_end_last":"2012-11-13T15:00:00-05:00","gmt_time_start":"2012-11-13 19:00:00","gmt_time_end":"2012-11-13 20:00:00","gmt_time_end_last":"2012-11-13 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/www.physics.gatech.edu\/seminars-colloquia\/series\/soft-condensed-matter-and-biophysics\/volkmar-heinrich-20121113","title":"https:\/\/www.physics.gatech.edu\/seminars-colloquia\/series\/soft-condensed-mat..."},{"url":"http:\/\/www.bme.ucdavis.edu\/people\/departmental-faculty\/profiles2\/volkmar-heinrich\/","title":"http:\/\/www.bme.ucdavis.edu\/people\/departmental-faculty\/profiles2\/volkmar-he..."}],"groups":[{"id":"126011","name":"School of Physics"}],"categories":[],"keywords":[{"id":"5230","name":"Biophysics"},{"id":"167300","name":"soft condensed matter"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:alison.morain@physics.gatech.edu\u0022\u003Ealison.morain@physics.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}