{"178421":{"#nid":"178421","#data":{"type":"event","title":"ChBE Seminar Series\u2013Dr. Stacy Finley","body":[{"value":"\u003Cp\u003EIn addition to its annual lectures, ChBE hosts a weekly seminar throughout the year with invited lecturers who are prominent in their fields. Unless otherwise noted, all seminars are held on Wednesdays in the Molecular Science and Engineering Building (\u0022M\u0022 Building) in G011 (Cherry Logan Emerson Lecture Theater) at 4:00 p.m. Refreshments are served at 3:30 p.m. in the Emerson-Lewis Reception Salon.\u003C\/p\u003E\u003Cp\u003E_______________\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EOf Mice and Men:\u0026nbsp;Computational models to investigate anti-angiogenic cancer therapies targeting the\u0026nbsp;VEGF pathway\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAngiogenesis, the formation of new blood vessels from pre-existing vasculature, is a tightly\u0026nbsp;regulated biological process involved in physiological function such as wound healing and\u0026nbsp;exercise, as well as in pathological conditions, including preeclampsia, ischemic heart disease,\u0026nbsp;and cancer. Inducing angiogenesis is a hallmark of cancer, as tumors cannot grow beyond 1\u0026nbsp;mm in diameter without eliciting the formation of blood capillaries to supply oxygen and other\u0026nbsp;nutrients. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis and its\u0026nbsp;role in cancer biology has been widely studied. Given the action of VEGF in promoting\u0026nbsp;angiogenesis, it has been targeted in various cancer treatments.\u003C\/p\u003E\u003Cp\u003ESystems biology approaches, including experiment-based computational modeling, are useful in\u0026nbsp;gaining insight into the complexity of tumor angiogenesis. These models provide a framework to\u0026nbsp;test biological hypotheses and optimize effective therapies that aim to inhibit tumor vascularization and growth. Here, I describe the development of whole-body, molecular-detailed\u0026nbsp;compartment models of VEGF kinetics and transport in mice and humans and the application of\u0026nbsp;these models to predict the effect of various anti-angiogenic therapies that inhibit VEGF. The\u0026nbsp;mouse model has been fit to available experimental data and complements pre-clinical drug studies, and the human model is applied to interpret clinical data. Both models reproduce\u0026nbsp;experimental observations and predict the dynamics of VEGF in the body. Importantly, the\u0026nbsp;models simulate the effects of intravenous administration of anti-VEGF agents. The model\u0026nbsp;predictions are relevant to the clinical application of VEGF-targeting therapies and generate\u0026nbsp;testable hypotheses that can aid in elucidating the mechanism of action of anti-VEGF agents. This work is useful for the development and optimization of personalized cancer treatment\u0026nbsp;strategies that target the VEGF pathway.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":"","uid":"27741","created_gmt":"2012-12-18 16:11:50","changed_gmt":"2016-10-08 02:01:35","author":"Katie Brown","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2013-01-30T15:00:00-05:00","event_time_end":"2013-01-30T16:00:00-05:00","event_time_end_last":"2013-01-30T16:00:00-05:00","gmt_time_start":"2013-01-30 20:00:00","gmt_time_end":"2013-01-30 21:00:00","gmt_time_end_last":"2013-01-30 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":["free_food"],"related_links":[{"url":"http:\/\/chbe.gatech.edu\/seminars","title":"ChBE Seminar Series"}],"groups":[{"id":"1240","name":"School of Chemical and Biomolecular Engineering"}],"categories":[],"keywords":[{"id":"167445","name":"School of Chemical and Biomolecular Engineering"},{"id":"167323","name":"Seminars"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EChBE Communications\u003Cbr \/\u003E(404) 894-1838\u003Cbr \/\u003Eevents@chbe.gatech.edu\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}