{"185001":{"#nid":"185001","#data":{"type":"event","title":"Graduate and Postdoc (GaP) Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EPhil Keegan - Advisor, Manu Platt, PhD\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0022Role of Shear Stress on Endothelial Cell Regulation of Elastases and Collagenases under the Unique Inflammatory Conditions of Sickle Cell Disease\u0022\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cbr \/\u003ERemodeling of cerebral arteries in children as early as 3 years old with sickle cell disease results in a 220-fold increase in stroke risk; however, the underlying mechanisms have not been elucidated. Here, we investigate how the pathological hemodynamic and inflammatory environment unique to sickle cell disease activates cathepsins, powerful proteases involved in arterial remodeling, in order to identify novel therapeutic targets.\u003Cbr \/\u003E\u003Cstrong\u003E\u003Cbr \/\u003EJenna Wilson - Advisor, Todd McDevitt, PhD\u003Cbr \/\u003E\u003Cbr \/\u003E\u0022A Microfluidic Tool for Single-cell Analysis of Embryoid Body Heterogeneity\u0022\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cbr \/\u003EEmbryonic stem cells are often cultured as embryoid bodies (EBs), a platform which allows for spontaneous differentiation and results in phenotypic heterogeneity. To explore and assess this heterogeneity, a microfluidic-based analytical method will be described which determines the characteristics of individual cells that make up a single EB.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Graduate and Post-Doc (GaP) Seminar Series is a weekly event of research presentations by two graduate students or post-docs conducting bio-related research.\u0026nbsp; The series is organized and sponsored by the Parker H. Petit Institute for Bioengineering and Bioscience (IBB) with additional support from the Wallace H. Coulter Department of Biomedical Engineering. It is held every Wednesday at 12:00pm in IBB 1128 and refreshments are provided. If your research group or department would like to present at future seminars, please contact \u003Ca href=\u0022mailto:manu.platt@bme.gatech.edu\u0022\u003EManu Platt, PhD\u003C\/a\u003E.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Phil Keegan and Jenna Wilson presenting"}],"uid":"27195","created_gmt":"2013-01-17 15:27:30","changed_gmt":"2016-10-08 02:02:10","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2013-02-27T11:00:00-05:00","event_time_end":"2013-02-27T12:00:00-05:00","event_time_end_last":"2013-02-27T12:00:00-05:00","gmt_time_start":"2013-02-27 16:00:00","gmt_time_end":"2013-02-27 17:00:00","gmt_time_end_last":"2013-02-27 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"65807":{"id":"65807","type":"image","title":"GaP Seminar Series","body":null,"created":"1449176884","gmt_created":"2015-12-03 21:08:04","changed":"1475894582","gmt_changed":"2016-10-08 02:43:02","alt":"GaP Seminar Series","file":{"fid":"192409","name":"GaP_Logo_-_square.png","image_path":"\/sites\/default\/files\/images\/GaP_Logo_-_square_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/GaP_Logo_-_square_0.png","mime":"image\/png","size":9759,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/GaP_Logo_-_square_0.png?itok=xFPLw_YI"}},"194681":{"id":"194681","type":"image","title":"Phil Keegan","body":null,"created":"1449179891","gmt_created":"2015-12-03 21:58:11","changed":"1475894846","gmt_changed":"2016-10-08 02:47:26","alt":"Phil Keegan","file":{"fid":"196390","name":"keeganphil.jpg","image_path":"\/sites\/default\/files\/images\/keeganphil_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/keeganphil_0.jpg","mime":"image\/jpeg","size":70035,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/keeganphil_0.jpg?itok=y0PlzdEL"}},"194671":{"id":"194671","type":"image","title":"Jenna Wilson","body":null,"created":"1449179891","gmt_created":"2015-12-03 21:58:11","changed":"1475894816","gmt_changed":"2016-10-08 02:46:56","alt":"Jenna Wilson","file":{"fid":"196389","name":"wilsonjenna.jpg","image_path":"\/sites\/default\/files\/images\/wilsonjenna_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/wilsonjenna_0.jpg","mime":"image\/jpeg","size":30225,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/wilsonjenna_0.jpg?itok=0ErQMhTt"}}},"media_ids":["65807","194681","194671"],"related_links":[{"url":"http:\/\/www.ibb.gatech.edu\/gap-seminar-series","title":"GaP Seminar Series Schedule"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"12813","name":"GaP Seminar"},{"id":"248","name":"IBB"},{"id":"33321","name":"Jenna Wilson"},{"id":"55711","name":"phil keegan"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:manu.platt@bme.gatech.edu\u0022\u003EManu Platt, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}