207281 event 1366207796 1475892201 Inhwan Jang
Advisor - Hanjoong Jo, PhD

"Identification of novel mechanosensitive inflammatory genes in endothelium by combined mouse gene array and functional Drosophila siRNA screening"

 We conducted a large-scale in vivo Drosophila screen to discover novel mechanosensitive, inflammatory genes. From this screening, we identified smarcd3, psmd12 (mouse ortholog of RPN5), and IRE1 as novel regulators of NFκB in inflammatory response. Of these, smarcd3 acts as an anti-inflammatory repressor of NFκB in endothelial cells, which might play an important role in regulating endothelial inflammation in a shear-responsive manner.

]]> The Graduate and Post-Doc (GaP) Seminar Series is a weekly event of biotechnology related research presentations by two graduate students or post-docs of IBB and is co-sponsored by BME. It is held every Wednesday at 12:00pm in IBB 1128 and refreshments are provided. If your research group or department would like to present at future seminars, please contact Manu Platt, PhD.

]]> 65807 image 192409 image/png Manu Platt, PhD

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