{"213781":{"#nid":"213781","#data":{"type":"news","title":"Grand Challenges Grant Supports Tissue Engineered Model of Lymphatic System","body":[{"value":"\u003Cp\u003EThe Georgia Institute of Technology has announced that it is a Grand Challenges Explorations winner, an initiative funded by the Bill \u0026amp; Melinda Gates Foundation. J. Brandon Dixon, an assistant professor in Georgia Tech\u2019s George W. Woodruff School of Mechanical Engineering, will pursue an innovative global health and development research project, titled \u201cLymphatic on a chip as a model for lymphatic filariasis (LF) parasites.\u201d\u003C\/p\u003E\u003Cp\u003EGrand Challenges Explorations (GCE) funds individuals worldwide to explore ideas that can break the mold in how we solve persistent global health and development challenges. Dixon\u2019s project is one of the Grand Challenges Explorations Round 10 grants announced May 21 by the Bill \u0026amp; Melinda Gates Foundation.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETo receive funding, Dixon and other Grand Challenges Explorations Round 10 winners demonstrated in a two-page online application a bold idea in one of four critical global heath and development topic areas that included agriculture development, neglected tropical diseases and communications.\u003C\/p\u003E\u003Cp\u003EThe grant will fund development of a tissue-engineered model of the human lymphatic system that will support laboratory research into lymphatic filariasis, a parasitic disease known to cause elephantiasis. According to the World Health Organization, the mosquito-borne disease affects more than 120 million persons in tropical areas of the world, and can cause severe disfigurement. The parasitic worms that cause lymphatic filariasis are difficult to study because the most common species of the parasite can survive only in humans. While less common species can be maintained in felines or gerbils, they are challenging to culture long-term outside the host. The model that Dixon plans to develop would use human cells housed within fabricated microfluidic devices to closely simulate the environment where the adult worms live within their hosts, allowing the parasites to be studied longer term in vitro.\u003C\/p\u003E\u003Cp\u003E\u201cWe would use this human lymphatic environment on a microfluidic chip to study the progression of the disease and the communication between the host and the parasite,\u201d explained Dixon, who is also a member of Georgia Tech\u2019s Institute for Bioengineering and Bioscience. \u201cWe could also scale this up to evaluate new pharmaceutical compounds that could potentially target the worm.\u201d\u003C\/p\u003E\u003Cp\u003EThe microfluidic system will include human lymphatic endothelial cells, which are the primary cell type in contact with the worms in the body. Researchers will also include human dermal fibroblasts \u2013 an important cell type in the skin where the mosquito first delivers the parasitic infection \u2013 and the immune cells that fight infection long-term. Beyond creating the cellular environment needed to support the worms, the researchers will also design a matrix to house the living cells, determine which hormones and nutrients are needed, and establish appropriate fluid flow rates for the microfluidic devices to recreate the hydrodynamic forces the worms encounter in the body. The devices will be integrated into an optical platform that would allow researchers to quantify the activity of the worms over extended periods of time using automated image analysis algorithms.\u003C\/p\u003E\u003Cp\u003EBeyond studying lymphatic filariasis, Dixon believes a lymphatic system on a chip could ultimately support broader areas of research into disorders of this bodily system. The human lymphatic system has historically been underappreciated and is challenging to study because it is difficult to image, the vessels involved are small and the flow rates are very low compared to blood vasculature.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbout Grand Challenges Explorations\u003C\/strong\u003E\u003Cbr \/\u003EGrand Challenges Explorations is a $100 million initiative funded by the Bill \u0026amp; Melinda Gates Foundation. Launched in 2008, over 800 people in more than 50 countries have received Grand Challenges Explorations grants. The grant program is open to anyone from any discipline and from any organization. The initiative uses an agile, accelerated grant-making process with short two-page online applications and no preliminary data required. Initial grants of $100,000 are awarded two times a year. Successful projects have the opportunity to receive a follow-on grant of up to $1 million.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EResearch News\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorgia Institute of Technology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003E177 North Avenue\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAtlanta, Georgia\u0026nbsp; 30332-0181\u0026nbsp; USA\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMedia Relations Contact\u003C\/strong\u003E: John Toon (404-894-6986)(\u003Ca href=\u0022mailto:jtoon@gatech.edu\u0022\u003Ejtoon@gatech.edu\u003C\/a\u003E).\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech has won a Grand Challenges Explorations Grant from the Bill \u0026amp; Melinda Gates Foundation.\u0026nbsp; J. Brandon Dixon, assistant professor in Georgia Tech\u2019s George W. Woodruff School of Mechanical Engineering, will pursue an innovative global health and development research project, titled \u201cLymphatic on a chip as a model for lymphatic filariasis (LF) parasites.\u201d\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Georgia Tech has won a Grand Challenges Exploration grant to support development of a lymphatic system on a chip."}],"uid":"27303","created_gmt":"2013-05-20 11:14:39","changed_gmt":"2016-10-08 03:14:16","author":"John Toon","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2013-05-20T00:00:00-04:00","iso_date":"2013-05-20T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"213751":{"id":"213751","type":"image","title":"Lymphatic on a Chip","body":null,"created":"1449180096","gmt_created":"2015-12-03 22:01:36","changed":"1475894876","gmt_changed":"2016-10-08 02:47:56","alt":"Lymphatic on a Chip","file":{"fid":"197005","name":"lymphatic-system22273.jpg","image_path":"\/sites\/default\/files\/images\/lymphatic-system22273_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/lymphatic-system22273_0.jpg","mime":"image\/jpeg","size":912466,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/lymphatic-system22273_0.jpg?itok=oOKu1zNN"}},"213761":{"id":"213761","type":"image","title":"Lymphatic on a Chip2","body":null,"created":"1449180096","gmt_created":"2015-12-03 22:01:36","changed":"1475894876","gmt_changed":"2016-10-08 02:47:56","alt":"Lymphatic on a Chip2","file":{"fid":"197006","name":"lymphatic-system79385.jpg","image_path":"\/sites\/default\/files\/images\/lymphatic-system79385_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/lymphatic-system79385_0.jpg","mime":"image\/jpeg","size":711158,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/lymphatic-system79385_0.jpg?itok=ZL9fK7Lb"}}},"media_ids":["213751","213761"],"groups":[{"id":"1214","name":"News Room"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"146","name":"Life Sciences and Biology"}],"keywords":[{"id":"23201","name":"brandon dixon"},{"id":"9315","name":"Gates Foundation"},{"id":"66571","name":"Grand Challenges Explorations"},{"id":"5634","name":"Institute for Bioengineering and Bioscience"},{"id":"66561","name":"lymphatic"},{"id":"66581","name":"lymphatic filariasis"},{"id":"12427","name":"microfluidics"},{"id":"7631","name":"parasite"},{"id":"167377","name":"School of Mechanical Engineering"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EJohn Toon\u003C\/p\u003E\u003Cp\u003EResearch News\u003C\/p\u003E\u003Cp\u003E\u003Ca href=\u0022mailto:jtoon@gatech.edu\u0022\u003Ejtoon@gatech.edu\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E(404) 894-6986\u003C\/p\u003E","format":"limited_html"}],"email":["jtoon@gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}