{"224291":{"#nid":"224291","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Understanding and Improving Platinum Anticancer Drugs\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EStephen J. Lippard, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EArthur Amos Noyes Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EChemistry Department\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMassachusetts Institute of Technology\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EPlatinum compounds are a mainstay of cancer therapy, with more than half of all patients receiving an infusion of one of three FDA approved drugs (cisplatin, carboplatin, and oxaliplatin). The biological action of cisplatin was discovered by serendipity in the late 1960s. Our laboratory has subsequently established the chemical nature of events leading up to the binding of platinum anticancer drugs to DNA, their principal target in the nucleus of cancer cells. The major adducts are cross-links between two adjacent nucleotides on one strand of the double helix, which bend and distort the duplex, interrupting cellular processing by RNA and DNA polymerases. We discovered more recently that related platinum compounds, capable of forming only a single link to DNA, are also extremely active against cancer cells, leading to exciting new strategies and candidates for drug development. Details of how these \u0027monofunctional\u0027 compounds work will be described. From the chemical principles learned in the process have emerged a much larger family of anticancer drug candidates, including those based on osmium and rhenium in addition to platinum.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003EStephen J. Lippard, whose research spans the fields of biological and inorganic chemistry, is the Arthur Amos Noyes Professor of Chemistry at the Massachusetts Institute of Technology.\u003Cbr \/\u003E\u003Cbr \/\u003ELippard studies biological interactions involving metal ions, focusing on reactions and physical and structural properties of metal complexes. Such complexes can be useful as cancer drugs and as models for the active sites of metalloproteins. Metal ions also promote key biological reactions in enzymes and metal complexes can be employed to sense biological signaling agents.\u003Cbr \/\u003E\u003Cbr \/\u003EThis is event is jointly sponsored by the Integrated Cancer Research Center and Georgia Tech\u0027s School of Chemistry and Biochemistry.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics. \u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003EThis event is jointly sponsored with Georgia Tech\u0027s School of Chemistry and Biochemistry.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Understanding and Improving Platinum Anticancer Drugs\u0022 - Stephen J. Lippard, PhD - Massachusetts Institute of Technology"}],"uid":"27195","created_gmt":"2013-07-23 09:26:24","changed_gmt":"2017-04-13 21:24:01","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-04-22T17:00:00-04:00","event_time_end":"2014-04-22T18:00:00-04:00","event_time_end_last":"2014-04-22T18:00:00-04:00","gmt_time_start":"2014-04-22 21:00:00","gmt_time_end":"2014-04-22 22:00:00","gmt_time_end_last":"2014-04-22 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.ibb.gatech.edu\/icrc-seminars","title":"ICRC Seminar Series schedule"},{"url":"http:\/\/web.mit.edu\/lippardlab\/","title":"Lippard lab website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}