{"226661":{"#nid":"226661","#data":{"type":"event","title":"Breakfast Club Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Osteoimmunology:\u0026nbsp; Exploring the Role of the Immune System in Regulating Bone in Health and Disease\u0022\u003Cbr \/\u003E\u003Cbr \/\u003ERoberto Pacifici, MD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGarland Herndon Professor of Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Endocrinology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EEmory University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EOur laboratory has pioneered the field of osteoimmunology.\u0026nbsp; The laboratory is specialized in conducting in vivo studies in mice treated with PTH or subjected to ovariectomy.\u0026nbsp; We use genetic models, retroviral transduction, bone marrow transplantation, T cell transfer and in vivo treatments with hormones, cytokines and antibodies.\u0026nbsp; Typical end points include sophisticated flow cytometric analysis of bone marrow cells and microCT and histomorphometric analysis of bone structure.\u0026nbsp; The lab is equipped with in vivo and in vitro microCT scanners.\u003Cbr \/\u003E\u003Cbr \/\u003EWe have been the first to recognize that T cells play a pivotal role in the mechanism of action of estrogen and PTH in bone by regulating osteoclast and osteoblast development and function.\u0026nbsp; We have shown that mice lacking T cells are protected against the bone loss induced by estrogen deficiency and hyperparathyroidism.\u0026nbsp; We have has also shown that T cells regulate the number and function of mesenchymal stem cells. We are currently investigating the mechanism by which T cells mediate the expansion of hemopoietic stem cells caused by estrogen deficiency and PTH.\u0026nbsp; Another main focus is to understand why \u201cintermittent\u201d PTH treatment causes bone anabolism while \u201ccontinuous\u201d PTH treatment causes bone loss. We hypothesize that the response to PTH depends on the effects of this hormone on T cell production of Wnt10b and TNF.\u0026nbsp; A third project involves the use of intravital microscopy to study the effects of estrogen deficiency and PTH on the trafficking of T cells in the bone marrow.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Osteoimmunology:  Exploring the Role of the Immune System in Regulating Bone in Health and Disease\u0022 - Roberto Pacifici, MD - Emory University"}],"uid":"27195","created_gmt":"2013-08-05 14:33:37","changed_gmt":"2016-10-08 02:04:05","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2013-12-10T07:30:00-05:00","event_time_end":"2013-12-10T08:30:00-05:00","event_time_end_last":"2013-12-10T08:30:00-05:00","gmt_time_start":"2013-12-10 12:30:00","gmt_time_end":"2013-12-10 13:30:00","gmt_time_end_last":"2013-12-10 13:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"http:\/\/www.biomed.emory.edu\/PROGRAM_SITES\/IMP\/pacifici_r.html","title":"Pacifici lab website"},{"url":"http:\/\/www.ibb.gatech.edu\/breakfast-club","title":"IBB Breakfast Club"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}