{"265571":{"#nid":"265571","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Dysregulation of Autophagy and Malignant Behavior in Ovarian Cancer\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003ECiro Isidoro, MD, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor of Cell and Molecular Pathology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ESchool of Sciences and School of Biotechnology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAdjunct Professor of Environmental Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ESchool of Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversit\u00e0 del Piemonte Orientale \u0022A. Avogadro\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EAutophagy is a cellular process of lysosomal degradation of aged, redundant or abnormal self molecules or organelles. In normal cells, autophagy runs at low basal level to allow macromolecules turnover, and it prevents cell transformation through the constant elimination of pro-oxidant molecules. Autophagy has been implicated in various malignant aspects of cancer, including the resistance of cancer cells to depletion of nutrients, as it occurs in fast growing and insufficiently vascularized tumours, and to chemotherapeutics. Autophagy has also been implicated in cell migration and tumour invasion. Autophagy is regulated by a certain group of oncogenes and tumour suppressor genes and by several microRNAs. Here I present our experimental data supporting the involvement of Autophagy in cell migration and resistance to chemotherapeutic in ovarian cancer, and the role of genetic and epigenetic factors in (dys)-regulation of Autophagy.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Dysregulation of Autophagy and Malignant Behavior in Ovarian Cancer\u0022 - Ciro Isidoro, MD, PhD - Universit\u00e0 del Piemonte Orientale \u0022A. Avogadro\u0022"}],"uid":"27195","created_gmt":"2014-01-09 15:07:38","changed_gmt":"2017-04-13 21:23:33","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-13T15:00:00-05:00","event_time_end":"2014-02-13T16:00:00-05:00","event_time_end_last":"2014-02-13T16:00:00-05:00","gmt_time_start":"2014-02-13 20:00:00","gmt_time_end":"2014-02-13 21:00:00","gmt_time_end_last":"2014-02-13 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.isidorolab.com\/","title":"Isodoro lab website"},{"url":"http:\/\/www.icrc.gatech.edu\/","title":"Integrated Cancer Research Center website"},{"url":"http:\/\/www.ibb.gatech.edu\/icrc-seminars","title":"ICRC Seminar Series schedule"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, PhD\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}