{"273911":{"#nid":"273911","#data":{"type":"event","title":"ImmunoEngineering Seminar Series","body":[{"value":"\u003Cp\u003EThe new Georgia Tech Center for ImmunoEngineering invites you to attend our ImmunoEngineering Trainee Seminar Series to bring together members of the bio community interested in and doing research in ImmunoEngineering.\u003Cbr \/\u003E\u003Cbr \/\u003ETo present:\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EJardin Leleux\u003Cbr \/\u003EKrishnendu Roy, PhD - Advisor\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003E\u0022Investigation of Pathogen-Mimicking Particles for Delivery of Vaccine Components in Murine Tumor Models\u0022\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EMany state-of-the-art cancer therapies result in serious side effects, recurrence and eventually lead to death. An alternative, tumor antigen based immunotherapy, has been explored extensively as a strategy to trigger self-maintained immunity against tumor burdens. Significant research has gone into developing delivery vehicles to continue to boost immune cell recognition and processing of these small molecules.\u003C\/p\u003E\u003Cp\u003EThe previous work done in the Roy lab has produced a microparticle delivery system that has successfully induced significant immune protection against tumor challenge. However, considering the hurdle of translating murine vaccines to clinically relevant ones, the current vaccine strategy still must be strengthened.\u003C\/p\u003E\u003Cp\u003EThe goal of this work is to produce a particle based vaccine delivery system that will induce a more robust, long-lasting immune response in murine cancer models. To optimize such vaccines, we will study how particle parameters, mainly size and antigen\/adjuvant release mechanism affect dendritic cell response in vitro and protection provided to tumor challenged mice in vivo.\u003C\/p\u003E\u0026nbsp;\u003Cbr \/\u003E\u003Cstrong\u003EMolly Ogle\u003C\/strong\u003E\u003Cp\u003E\u003Cstrong\u003EEd Botchwey, PhD - Advisor\u003Cbr \/\u003E\u003Cbr \/\u003E\u0022Tuning the immuno-regenerative response to inflammatory injury through sphingolipid therapeutics\u0022\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EControl of guided cell trafficking is essential for development, homeostasis, pathology, and regeneration. Modulation of the temporal-spatial recruitment of particular populations of inflammatory cells is a key target for promoting tissue regeneration, including microvascular growth and remodeling. Lipid mediators such as sphingosine-1-phosphate (S1P) have recently become recognized for their essential roles in spatial guidance, signaling, and ability to modify the sensitivity of cells to other chemokines and growth factors. Here we will discuss the role of S1P receptors in the differential recruitment of two distinct subsets of monocytes, CD45+CD11b+Ly6C+Gr1+CX3CR1lo inflammatory and CD45+CD11b+Ly6C-Gr1-CX3CR1hianti-inflammatory monocytes. We demonstrate that local sphingosine 1-phosphate receptor 3 agonism skews the balance of local cytokines from inflammatory to pro-regenerative and selectively recruits anti-inflammatory monocytes to remodeling vessels leading to enhanced arteriogenesis and angiogenesis. This work establishes a role for S1P receptor signaling in the local conditioning of tissues that preferentially recruit regenerative monocytes that can enhance healing outcomes, tissue regeneration, and biomaterial implant functionality.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EJardin Leleux and Molly Ogle presenting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"ImmunoEngineering Seminar Series"}],"uid":"27195","created_gmt":"2014-02-05 09:39:32","changed_gmt":"2017-04-13 21:23:15","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-04-04T10:30:00-04:00","event_time_end":"2014-04-04T11:30:00-04:00","event_time_end_last":"2014-04-04T11:30:00-04:00","gmt_time_start":"2014-04-04 14:30:00","gmt_time_end":"2014-04-04 15:30:00","gmt_time_end_last":"2014-04-04 15:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/immunoengineering.gatech.edu\/","title":"Immunoengineering website"},{"url":"http:\/\/botchweylab.gatech.edu\/","title":"Botchwey lab website"},{"url":"http:\/\/roylab.gatech.edu\/roy\/index.html","title":"Roy lab website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:writasse3@gatech.edu\u0022\u003EBilly Ritasse\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}