{"279121":{"#nid":"279121","#data":{"type":"news","title":"Self-Administration of Flu Vaccine with a Patch May be Feasible, Study Suggests","body":[{"value":"\u003Cp\u003EThe annual ritual of visiting a doctor\u2019s office or health clinic to receive a flu shot may soon be outdated, thanks to the findings of a new study published in the journal \u003Cem\u003EVaccine\u003C\/em\u003E.\u0026nbsp;\u0026nbsp; \u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe research, which involved nearly 100 people recruited in the metropolitan Atlanta area, found that test subjects could successfully apply a prototype vaccine patch to themselves. That suggests the self-administration of vaccines with microneedle patches may one day be feasible, potentially reducing administration costs and relieving an annual burden on health care professionals.\u003C\/p\u003E\u003Cp\u003EThe study also suggested that the use of vaccine patches might increase the rate at which the population is vaccinated against influenza. After comparing simulated vaccine administration using a patch and by conventional injection, the percentage of test subjects who said they\u2019d be vaccinated grew from 46 percent to 65 percent.\u003C\/p\u003E\u003Cp\u003E\u201cOur dream is that each year there would be flu vaccine patches available in stores or sent by mail for people to self-administer,\u201d said \u003Ca href=\u0022http:\/\/www.chbe.gatech.edu\/faculty\/prausnitz\u0022\u003EMark Prausnitz\u003C\/a\u003E, a Regent\u2019s professor in the \u003Ca href=\u0022http:\/\/www.chbe.gatech.edu\/\u0022\u003ESchool of Chemical and Biomolecular Engineering\u003C\/a\u003E at the Georgia Institute of Technology. \u201cPeople could take them home and apply them to the whole family. We want to get more people vaccinated, and we want to relieve health care professionals from the burden of giving these millions of vaccinations.\u201d\u003C\/p\u003E\u003Cp\u003EThe research on patient acceptance of vaccine patch immunization was published online February 11, 2014, by the journal \u003Cem\u003EVaccine\u003C\/em\u003E and will appear in a later edition of the print journal. In addition to Georgia Tech researchers, the project also included scientists from Emory University and the Centers for Disease Control and Prevention (CDC). Research into the use of microneedle patches for influenza vaccination has been supported by the National Institutes of Health (NIH).\u003C\/p\u003E\u003Cp\u003EThe study is believed to be the first published report of a head-to-head comparison between microneedle patches and traditional intramuscular injection for the administration of vaccines in human subjects. The patches consisted of arrays of 50 microscopic needles about as tall as the thickness of a few hairs. When used for vaccination, the patches would be pressed painlessly onto a person\u2019s forearm to carry vaccine into the outer layers of skin, where they would prompt an immune reaction from the body.\u003C\/p\u003E\u003Cp\u003EThe 91 study subjects, who had no previous experience with microneedle patches, were given brief instructions on applying the patches to themselves. Each volunteer applied three patches, had a fourth patch applied by a member of the research team, and received an injection of saline with a conventional hypodermic needle. Neither the patches nor the hypodermic needle actually carried a vaccine, and the study did not assess the efficacy of using microneedle patches for vaccinations in humans.\u003C\/p\u003E\u003Cp\u003EThe researchers evaluated how well the volunteers were able to self-administer the microneedle patches. After the subjects pressed the patches into their skin, the researchers applied a dye to highlight the tiny holes made by the microneedles. By photographing the administration sites and counting the number of holes, they were able to assess the accuracy of the application.\u003C\/p\u003E\u003Cp\u003E\u201cWe found that everyone was capable of administering a microneedle patch appropriately, though not everyone did on the first try,\u201d Prausnitz said.\u003C\/p\u003E\u003Cp\u003ESome of the subjects used an applicator that made a clicking sound when sufficient force was applied to the patch. Use of that feedback device improved the ability of subjects to correctly apply patches and virtually eliminated administration mistakes.\u003C\/p\u003E\u003Cp\u003EDuring the study, the volunteers were asked if they planned to receive a flu vaccination in the next year and if their intent to be vaccinated would change if it could be done with the patch. The percentage saying they\u2019d be vaccinated jumped from 46 to 65 percent when the patch was an option.\u003C\/p\u003E\u003Cp\u003E\u201cIf this holds for the population as a whole, that would have a tremendous impact on preventing disease and the cost associated with both influenza and the vaccination process,\u201d said Paula Frew, an assistant professor in the Emory University School of Medicine and a co-author of the study.\u003C\/p\u003E\u003Cp\u003EInterviewing the test subjects found strong support for self-administration of the flu vaccine.\u003C\/p\u003E\u003Cp\u003E\u201cIn addition to the preference for the vaccine patch, we found that a large majority of the people willing to be vaccinated would choose to self-administer the vaccine,\u201d said James Norman, the study\u2019s first author, who was a Georgia Tech graduate student when the research was conducted. \u0026nbsp;\u003C\/p\u003E\u003Cp\u003EStudy participants were asked to assess the pain associated with administering the patch and receiving the intramuscular injection. On a scale of one to 100, they rated the patches 1.5 on average, while the injection was rated 15.\u003C\/p\u003E\u003Cp\u003ELess than half the U.S. population receives vaccination against influenza each year. Several thousand Americans die of complications from the flu each year, and as many as 200,000 are hospitalized. Increasing the immunization rate could cut the deaths, hospitalizations and costs associated with the disease, Prausnitz noted.\u003C\/p\u003E\u003Cp\u003EUse of a vaccine patch could potentially also reduce the cost of vaccination programs. For influenza, the cost of storing and administering the vaccine \u2013 along with patient time to visit a clinic \u2013 accounts for as much as three-quarters of the total cost. If microneedle vaccine patches could be produced for about the same cost as current flu vaccines, self-administration could provide significant cost savings to the nation\u2019s health care system.\u003C\/p\u003E\u003Cp\u003EAnimal studies have shown that microneedle patches are at least as good as conventional intramuscular injections at conferring immunity to influenza. Prausnitz and his research team plan to begin a Phase 1 clinical study of the vaccine patches in humans during the spring of 2015. If that study shows promise, it could lead to larger studies and development of commercial patch manufacture.\u003C\/p\u003E\u003Cp\u003EIf all goes well, the vaccine patch could be available within five years. Prausnitz expects it to be administered first by health care professionals before being made available for self-administration.\u003C\/p\u003E\u003Cp\u003EIn addition to those already named, the study also involved Martin I. Meltzer, senior health economist with the CDC, and two Georgia Tech researchers: Jaya M. Arya and Maxine A. McClain.\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EMark Prausnitz is an inventor on patents that have been licensed to companies developing microneedle-based products, is a paid advisor to companies developing microneedle-based products, and is a founder\/shareholder of companies developing microneedle-based products. This potential conflict of interest has been disclosed and is managed by Georgia Tech and Emory University.\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EResearch on the use of microneedle patches for influenza vaccination has been supported by the National Institute of Biomedical Imaging and Bioengineering, part of the National Institutes of Health (NIH\/NIBIB), under award R01EB006369. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECITATION\u003C\/strong\u003E: James J. Norman, et al., \u201cMicroneedle Patches: Usability and Acceptability for Self-Vaccination Against Influenza,\u201d (Vaccine, 2014). (\u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.vaccine.2014.01.076\u0022\u003Ehttp:\/\/dx.doi.org\/10.1016\/j.vaccine.2014.01.076\u003C\/a\u003E)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EResearch News\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorgia Institute of Technology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003E177 North Avenue\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAtlanta, Georgia\u0026nbsp; 30332-0181\u0026nbsp; USA\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMedia Relations Contacts\u003C\/strong\u003E: John Toon (404-894-6986) (\u003Ca href=\u0022mailto:jtoon@gatech.edu\u0022\u003Ejtoon@gatech.edu\u003C\/a\u003E) or Brett Israel (404-385-1933) (\u003Ca href=\u0022mailto:brett.israel@comm.gatech.edu\u0022\u003Ebrett.israel@comm.gatech.edu\u003C\/a\u003E).\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EWriter\u003C\/strong\u003E: John Toon\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe annual ritual of visiting a doctor\u2019s office or health clinic to receive a flu shot may soon be outdated, thanks to the findings of a new study published in the journal \u003Cem\u003EVaccine\u003C\/em\u003E.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Microneedle patches may allow self-administration of influenza vaccine, a new study shows."}],"uid":"27303","created_gmt":"2014-02-26 10:41:11","changed_gmt":"2016-10-08 03:15:55","author":"John Toon","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2014-02-26T00:00:00-05:00","iso_date":"2014-02-26T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"hg_media":{"279091":{"id":"279091","type":"image","title":"Microneedle Patch Comparison","body":null,"created":"1449244168","gmt_created":"2015-12-04 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application","file":{"fid":"198862","name":"patch-application.png","image_path":"\/sites\/default\/files\/images\/patch-application_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/patch-application_0.png","mime":"image\/png","size":2544990,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/patch-application_0.png?itok=EDBVMObS"}}},"media_ids":["279091","279101","279111"],"groups":[{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"135","name":"Research"}],"keywords":[{"id":"296","name":"Flu"},{"id":"764","name":"immunization"},{"id":"765","name":"influenza"},{"id":"495","name":"Mark Prausnitz"},{"id":"13653","name":"microneedle patch"},{"id":"7496","name":"microneedles"},{"id":"167445","name":"School of Chemical and Biomolecular 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