{"280541":{"#nid":"280541","#data":{"type":"event","title":"CSE Seminar: Anthony Gitter","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ESpeaker:\u003C\/strong\u003E Anthony Gitter\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ELinking the Signaling Cascades and Dynamic Regulatory Networks Controlling Infection Response\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ECells undergo rapid and drastic changes to mount a response to pathogen infection.\u0026nbsp; The response is triggered when upstream proteins detect the pathogen and propagate signals via cascades of protein-protein interactions to transcription factors, which selectively activate or inhibit genes.\u0026nbsp; Although these upstream initiators and the resulting transcriptional effects can be characterized experimentally, the intermediate proteins driving signaling and transcription cannot be directly observed.\u0026nbsp; We present a technique for integrating large-scale data sources to predict temporal transcription factor activity as well as the directed signaling pathways that activate these regulators.\u0026nbsp; Studies of stress response in yeast validate our algorithm\u2019s ability to recover known pathways and identify missing participants.\u0026nbsp; Our approach also provides new insights into the human response to influenza infection.\u0026nbsp; The pathways we recover can be used to accurately predict RNA interference effects by estimating the impact a gene knockdown has on downstream transcription factors.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003EBio:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAnthony Gitter is a joint postdoctoral researcher at Microsoft Research New England and the Department of Biological Engineering at the Massachusetts Institute of Technology.\u0026nbsp; His PhD in Computer Science is from Carnegie Mellon University.\u0026nbsp; His computational systems biology research involves using probabilistic graphical models and graph theory to model how biological networks are perturbed in human diseases.\u0026nbsp; Specific interests include viral infection, cancer, and the dynamics of biological processes.\u0026nbsp; He was awarded a National Science Foundation Graduate Research Fellowship, and his study of temporal stress responses was recognized as a top ten paper of 2012-2013 in regulatory and systems genomics.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;~~~~~~~~\u003C\/p\u003E\u003Cp\u003ECSE-seminar mailing list: \u003Cbr \/\u003E\u003Ca href=\u0022mailto:CSE-seminar@mailman.cc.gatech.edu\u0022\u003ECSE-seminar@mailman.cc.gatech.edu\u003C\/a\u003E\u003Cbr \/\u003E\u003Ca href=\u0022https:\/\/mailman.cc.gatech.edu\/mailman\/listinfo\/cse-seminar\u0022\u003Ehttps:\/\/mailman.cc.gatech.edu\/mailman\/listinfo\/cse-seminar\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Linking the Signaling Cascades and Dynamic Regulatory Networks Controlling Infection Response"}],"uid":"27439","created_gmt":"2014-03-04 13:21:33","changed_gmt":"2017-04-13 21:23:02","author":"Lometa Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-14T19:00:00-04:00","event_time_end":"2014-03-14T20:00:00-04:00","event_time_end_last":"2014-03-14T20:00:00-04:00","gmt_time_start":"2014-03-14 23:00:00","gmt_time_end":"2014-03-15 00:00:00","gmt_time_end_last":"2014-03-15 00:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"47223","name":"College of Computing"},{"id":"50875","name":"School of Computer Science"},{"id":"50876","name":"School of Interactive Computing"},{"id":"50877","name":"School of Computational Science and Engineering"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ESrinivas Aluru, Professor CSE, \u003Ca href=\u0022mailto:aluru@cc.gatech.edu\u0022 target=\u0022_blank\u0022\u003Ealuru@cc.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}