{"285041":{"#nid":"285041","#data":{"type":"event","title":"ChBE Seminar Series\u2013Dr. K. Dane Wittrup","body":[{"value":"\u003Cp\u003EIn addition to its annual lectures, ChBE hosts a weekly seminar throughout the year with invited lecturers who are prominent in their fields. Unless otherwise noted, all seminars are held on Wednesdays in the Molecular Science and Engineering Building (\u0022M\u0022 Building) in G011 (Cherry Logan Emerson Lecture Theater) at 4:00 p.m. Refreshments are served at 3:30 p.m. in the Emerson-Lewis Reception Salon.\u003C\/p\u003E\u003Cp\u003E______________\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMultitasking Anti-Cancer Biotherapeutics\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ECombining multiple binding domains into single macromolecular assemblies enables novel approaches to cancer therapeutic development. Examples of such multispecific strategies will be presented including: pretargeted radioimmunotherapy; triepitopic receptor clustering and downregulation; and targeted endosomal potentiation for macromolecular payload release. The primary synthetic approach is to use combinatorial libraries of protein displayed on the surface of yeast cells, and to select the desired binding properties by directed evolution. A common analytical thread throughout this\u0026nbsp;work is to formulate simple, reductionist kinetic schema for these complex systems that help to elucidate key parameters and rate processes.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Multitasking Anti-cancer Biotherapeutics"}],"uid":"27982","created_gmt":"2014-03-24 10:50:35","changed_gmt":"2016-10-08 02:07:18","author":"Kevin Guger","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-26T21:00:00-04:00","event_time_end":"2014-03-26T22:00:00-04:00","event_time_end_last":"2014-03-26T22:00:00-04:00","gmt_time_start":"2014-03-27 01:00:00","gmt_time_end":"2014-03-27 02:00:00","gmt_time_end_last":"2014-03-27 02:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/web.mit.edu\/kdw-lab\/","title":"Wittrup\u0027s Research Website"}],"groups":[{"id":"1240","name":"School of Chemical and Biomolecular Engineering"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EChBE Communications\u003Cbr \/\u003E (404) 894-1838\u003Cbr \/\u003E \u003Ca href=\u0022mailto:events@chbe.gatech.edu\u0022\u003Eevents@chbe.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}