{"294471":{"#nid":"294471","#data":{"type":"event","title":"PhD Proposal - He Zheng","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdaptive Shaping of Cortical Response Selectivity in the Vibrissa Pathway in Awake and Anesthetized States\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EGarrett Stanley, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDieter Jaeger, PhD (Emory University)\u003Cbr \/\u003ERobert Liu, PhD (Emory University)\u003Cbr \/\u003EAnna Roe, PhD (Vanderbilt University)\u003Cbr \/\u003EChris Rozell, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EThe brain is inundated with sensory stimuli every waking hour, yet we efficiently extract relevant information to form perceptions and make decisions. The efficient encoding of sensory information necessarily relies on the ability of the pathway to dynamically shift its operating regime, depending on the context under which external stimuli are processed, be it an environmental cue or internal brain state regulation. One embodiment of context-dependent information processing is sensory adaptation, which has been shown to shape the information flow in the sensory pathway and cortical selectivity to stimulus features. Using voltage-sensitive dye imaging in anesthetized rats and the paradigm of detection \/ spatial discrimination task by the ideal observer as a model for context-dependent information processing, I first quantify how adaptation shapes the cortical response to a stimulus in the vibrissa pathway and how the information for detecting and spatially discriminating the stimulus is differentially optimized. I further investigate the effect of adaptation in ethologically relevant contexts. Cortical activation and detection-discrimination tradeoff are quantified in relation to the degree of adaptation, which is modulated continuously by the frequency and velocity of the adapting stimulus. Finally, I will generalize the findings to awake animals and investigate the common effects of adaptation under anesthetized and awake states and potential differences in sensory information processing.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EAdaptive Shaping of Cortical Response Selectivity in the Vibrissa \u003Cbr \/\u003EPathway in Awake and Anesthetized States\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Adaptive Shaping of Cortical Response Selectivity in the Vibrissa  Pathway in Awake and Anesthetized States"}],"uid":"27349","created_gmt":"2014-05-01 15:31:34","changed_gmt":"2016-10-08 02:07:42","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-20T15:00:00-04:00","event_time_end":"2014-05-20T18:00:00-04:00","event_time_end_last":"2014-05-20T18:00:00-04:00","gmt_time_start":"2014-05-20 19:00:00","gmt_time_end":"2014-05-20 22:00:00","gmt_time_end_last":"2014-05-20 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003ELaura Paige\u003C\/strong\u003E - \u003Cstrong\u003EAcademic Advisor\u003C\/strong\u003E\u003Cbr \/\u003E 404-385-6655\u003Cbr \/\u003E 404-894-2291 (fax)\u003Cbr \/\u003E \u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003EEmail \u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}