{"298951":{"#nid":"298951","#data":{"type":"event","title":"Center for Immunoengineering Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Viral Gene Circuits: Simple Model Systems and a New Spectrum of Antiviral Targets\u0022\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003ELeor S. Weinberger, PhD\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EAssociate Investigator\u0026nbsp;\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EGladstone Institute of Virology and Immunology\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EAssociate Professor of Biochemistry \u0026amp; Biophysics\u0026nbsp;\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EUniversity of California, San Francisco\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003EViral gene circuits are bounded by many of the same design constraints as electrical circuits (e.g., signal-to-noise ratio) but rapidly mutating viruses, like HIV, evolved unique mechanisms to circumvent these circuitry barriers. \u0026nbsp;These adaptations are essential to the evolutionary fitness of viruses and offer targets for novel antiviral therapies. \u0026nbsp;I will describe two viral circuit adaptations, the first in HIV (Weinberger \u0026amp; Weinberger, Cell, 2013) and the second in the human herpesvirus CMV (Teng et al., \u003Cem\u003ECell\u003C\/em\u003E, 2012), the leading cause of birth defects and transplant rejections. \u0026nbsp;I will also discuss very recent work on disrupting and exploiting these circuit architectures for new therapies (Dar et al. \u003Cem\u003EScience\u003C\/em\u003E, in press).\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u0022Viral Gene Circuits: Simple Model Systems and a New Spectrum of Antiviral Targets\u0022 - Leor W. Weinberger, PhD - Gladstone Institutes, University of California, San Francisco\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Viral Gene Circuits: Simple Model Systems and a New Spectrum of Antiviral Targets\u0022 - Leor S. Weinberger, PhD - University of California, San Francisco"}],"uid":"27195","created_gmt":"2014-05-21 11:59:56","changed_gmt":"2017-04-13 21:22:32","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-29T16:00:00-04:00","event_time_end":"2014-05-29T17:00:00-04:00","event_time_end_last":"2014-05-29T17:00:00-04:00","gmt_time_start":"2014-05-29 20:00:00","gmt_time_end":"2014-05-29 21:00:00","gmt_time_end_last":"2014-05-29 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/labs.gladstone.ucsf.edu\/weinberger\/","title":"Weinberger lab website"}],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"},{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:melissa.kemp@bme.gatech.edu\u0022\u003EMelissa Kemp, PhD\u003C\/a\u003E - faculty host\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}