{"312801":{"#nid":"312801","#data":{"type":"event","title":"Yu-Qing Cao, Washington University","body":[{"value":"\u003Cp\u003ECalcium channels and migraine headache\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EYu-Qing Cao, Department of Anesthesiology and Pain Center, Washington University in St. Louis\u003C\/p\u003E\u003Cp\u003EAbstract: \u003Cbr \/\u003EMigraine headache is highly debilitating, poorly understood, and difficult to treat. Mutations of human P\/Q-type voltage-gated Ca\u003Csup\u003E2+ \u003C\/sup\u003Echannels (VGCCs) associated with familial hemiplegic migraine type 1 (FHM-1) offer a gateway toward understanding the pathophysiology of FHM-1 as well as common migraine. Loss-of-function P\/Q channel mutations cause a decrease of P\/Q-type current in all subtypes of primary afferent neurons (PANs) in the pain pathways. Interestingly, only the PANs encoding headache become hyper-excitable as the result of P\/Q mutations, consistent with the fact that FHM-1 patients show higher incidence of migraine headache but not other types of pain. Additional studies using a mouse model of headache suggest that P\/Q and other VGCCs are involved in the onset of migraine in general population, not just FHM-1 patients. Ongoing experiments focus on dissecting the contribution of individual VGCC subtypes to migraine pathophysiology and their potential as targets for new migraine therapeutics.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Calcium channels and migraine headache"}],"uid":"27964","created_gmt":"2014-08-06 09:20:06","changed_gmt":"2017-04-13 21:22:12","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-09-18T12:00:00-04:00","event_time_end":"2014-09-18T12:00:00-04:00","event_time_end_last":"2014-09-18T12:00:00-04:00","gmt_time_start":"2014-09-18 16:00:00","gmt_time_end":"2014-09-18 16:00:00","gmt_time_end_last":"2014-09-18 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"99001","name":"Yu-Qing Cao"},{"id":"9552","name":"Yuhong Fan"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EIf you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology\u0027s administrative office at \u003Ca href=\u0022mailto:bio-admin@biology.gatech.edu\u0022\u003Ebio-admin@biology.gatech.edu\u003C\/a\u003E.\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}