{"333061":{"#nid":"333061","#data":{"type":"event","title":"PhD Proposal Presentation - Aditi Sharma","body":[{"value":"\u003Cp\u003EAdvisor:\u003C\/p\u003E\u003Cp\u003EAndreas S. Bommarius, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECo-Advisors:\u003C\/p\u003E\u003Cp\u003ESven H. Behrens, Ph.D. (Georgia Institute of Technology) Yury O. Chernoff, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECommittee:\u003C\/p\u003E\u003Cp\u003EM. G. Fin, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EJulie A. Champion, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EStudies on Amyloid Aggregation and Cross-Species Prion Transmission\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAmyloids are an important class of proteins because of their involvement in a number of neurodegenerative diseases such as Alzheimer\u2019s disease, Parkinson\u2019s disease, and Huntington\u2019s disease. Notably, these proteins have a tendency to acquire a stable alternate conformation rich in beta-sheets and associate with each other to form fibrous ordered aggregates. Due to their unique properties and involvement in a number of fatal diseases there is a lot of interest in studying this class of proteins. Another characteristic of amyloidogenic proteins is that a given protein may adopt many distinct conformations, known as \u201cvariants\u201d or \u201cstrains\u201d. Once formed, a strain is efficiently reproduced under the same conditions on addition of the same prion protein. On the other hand, cross species transmission of prions is less efficient due to a \u201cspecies barrier\u201d which prevents the transmission of the prion state between prion proteins from different species with divergent sequences. The molecular basis of prion transmission and mechanisms of prion strain formation are not yet fully understood.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Studies on Amyloid Aggregation and Cross-Species Prion Transmission \u0022 Aditi Sharma\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Studies on Amyloid Aggregation and Cross-Species Prion Transmission \u0022"}],"uid":"27917","created_gmt":"2014-10-10 13:31:20","changed_gmt":"2017-04-13 21:21:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-24T15:00:00-04:00","event_time_end":"2014-10-24T17:00:00-04:00","event_time_end_last":"2014-10-24T17:00:00-04:00","gmt_time_start":"2014-10-24 19:00:00","gmt_time_end":"2014-10-24 21:00:00","gmt_time_end_last":"2014-10-24 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}