{"338801":{"#nid":"338801","#data":{"type":"event","title":"Nano@Tech: Nanotechnology for Ultrasensitive and Noninvasive Diagnostics","body":[{"value":"\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u003Cstrong\u003ENanotechnology for Ultrasensitive and Noninvasive Diagnostics\u003Cbr \/\u003EProfessor Gabriel Kwong\u003Cbr \/\u003ESchool of Biomedical Engineering, Georgia Institute of Technology\u003C\/strong\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E Biomarkers are increasingly important in the clinical management of complex diseases, yet our ability to discover new biomarkers remains limited by our dependence on endogenous biomolecules. Here I describe the development of \u201csynthetic biomarkers\u201d comprising protease-sensitive nanoparticles that perform three functions following administration: they target sites of disease, sense dysregulated protease activities, and release reporters into the host urine as indicators of disease. These urinary reporters are mass-encoded to allow multiplexed analysis by mass spectrometry, or functionalized with capture ligands to allow detection by low-cost paper tests in global health settings. By engineering nanoparticles to sense different proteases, I show that synthetic biomarkers may be used to noninvasively monitor liver fibrosis and reversal, detect dangerous pulmonary blood clots and detect cancer earlier compared to blood biomarkers. Synthetic biomarkers have the potential to significantly expand our repertoire of diagnostic nanomedicines, and may allow systems-level analysis of multi-enzymatic networks in health and disease.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBio:\u003C\/strong\u003E Dr. Kwong is an Assistant Professor of Biomedical Engineering of Georgia Tech and Emory School of Medicine. He earned his B.S. in Bioengineering with Highest Honors from University of California at Berkeley, his Ph.D. from Caltech and postdoctoral studies at MIT. His work has been published in leading scientific journals such as \u003Cem\u003ENature Biotechnology\u003C\/em\u003E and \u003Cem\u003ENature Medicine\u003C\/em\u003E, and profiled broadly including coverage in \u003Cem\u003EThe Economist, NPR, BBC,\u003C\/em\u003E and \u003Cem\u003EWGBH-2\u003C\/em\u003E, Boston\u2019s PBS station. Dr. Kwong has received multiple honors including the NIH Ruth L. Kirschstein National Research Service Award, named a \u201cFuture Leader in Cancer Research and Translation Medicine\u201d by the Massachusetts General Hospital in 2012, and awarded the Burroughs Wellcome Fund Career Award at the Scientific Interface in 2013 \u2013 a distinction given to the 10 most innovative cross-disciplinary investigators in the nation. He holds 7 issued or pending patents in cancer nanotechnology.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Join us for Nano@Tech as we welcome Professor Gabe Kwong, Coulter Department of Biomedical Engineering at the Georgia Institute of Technology"}],"uid":"27863","created_gmt":"2014-10-31 13:04:26","changed_gmt":"2017-04-13 21:21:18","author":"Christa Ernst","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-01-27T11:00:00-05:00","event_time_end":"2015-01-27T12:00:00-05:00","event_time_end_last":"2015-01-27T12:00:00-05:00","gmt_time_start":"2015-01-27 16:00:00","gmt_time_end":"2015-01-27 17:00:00","gmt_time_end_last":"2015-01-27 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":["free_food"],"groups":[{"id":"1271","name":"NanoTECH"},{"id":"197261","name":"Institute for Electronics and Nanotechnology"},{"id":"198081","name":"Georgia Electronic Design Center (GEDC)"},{"id":"213771","name":"The Center for MEMS and Microsystems Technologies"},{"id":"213791","name":"3D Systems Packaging Research Center"}],"categories":[],"keywords":[{"id":"108031","name":"College of Engineering; Coulter Department of Biomedical Engineering"},{"id":"108041","name":"Gabe Kwong"},{"id":"12701","name":"Institute for Electronics and Nanotechnology"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}