{"345031":{"#nid":"345031","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Using Molecular Interactions to Control Release Rate and Refilling of Drug Delivery Devices\u0022\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EHorst von Recum, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Biomedical Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ECase Western Reserve University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ECleveland, OH\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EControlled delivery of molecules has found its way into all walks of life from dishwasher detergent, to biomedical devices, to paint.\u0026nbsp;\u0026nbsp; In biomedical applications controlled drug delivery is used to provide appropriate dosing of therapeutics to meet physiological need.\u0026nbsp; For local drug delivery this also includes optimizing effects at the needed site, while bypassing some or all of the detrimental effects of systemic delivery.\u0026nbsp; One of the major factors that researchers in this field have to work with is Fick\u2019s First Law of Diffusion, namely that drug will follow a concentration gradient, which results in extremely rapid release in early time points followed by a longer period of much slower release.\u0026nbsp; Often times this bi-phasic release is not sufficient to address the biomedical problem, leaving the investigator only limited capacity for adjustment of polymer properties to modify the Diffusivity term of Fick\u2019s Law.\u0026nbsp; The von Recum lab has been exploring the use of intentionally designed molecular interactions to add additional factors controlling the rate of drug release, namely adding a specific affinity between drug and polymer, making this interaction become the rate limiting step.\u0026nbsp; This research field, termed \u201caffinity-based drug delivery\u201d is capable of reducing the burst phase and prolonging release from hours to days to months.\u0026nbsp; In addition, such controlled delivery devices, once empty still maintain their molecular pockets, which can be refilled for additional therapeutic windows, and periods of delivery.\u0026nbsp; In this work we will show applications ranging from device infection, cancer therapy, cardiovascular restenosis, and stem cell homing and proliferation in tissue engineering and regenerative medicine.\u0026nbsp; Further we will show how such devices are capable of being refilled in vivo and demonstrate additional therapeutic windows.\u0026nbsp; In closing we feel that the prolonged release, and refilling capacity of affinity-based drug delivery devices will open new fields of application previously not addressable by devices controlled by diffusion alone.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between the Petit Institute and the Biomedical Engineering department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute, room 1128, unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Using Molecular Interactions to Control Release Rate and Refilling of Drug Delivery Devices\u0022 - Horst von Recum, PhD - Case Western Reserve University"}],"uid":"27959","created_gmt":"2014-11-12 19:04:15","changed_gmt":"2017-04-13 21:21:09","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-05T10:00:00-05:00","event_time_end":"2015-03-05T11:00:00-05:00","event_time_end_last":"2015-03-05T11:00:00-05:00","gmt_time_start":"2015-03-05 15:00:00","gmt_time_end":"2015-03-05 16:00:00","gmt_time_end_last":"2015-03-05 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/bme.case.edu\/FacultyStaff\/PrimaryFaculty\/vonRecum\/","title":"von Recum lab website"},{"url":"http:\/\/petitinstitute.gatech.edu\/bioe-seminars","title":"Bioengineering Seminar Series website"},{"url":"http:\/\/petitinstitute.gatech.edu\/","title":"Petit Institute website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"1808","name":"graduate students"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host:\u0026nbsp; \u003Ca href=\u0022mailto:johnna.temenoff@bme.gatech.edu\u0022\u003EJohnna Temenoff\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}