{"346151":{"#nid":"346151","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EInteraction of Angiogenic Microvessels with the Extracellular Matrix\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJeffrey A. Weiss, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor of Bioengineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAdjunct Professor of Orthopaedics and School of Computing\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EFaculty Member, Scientific Computing and Imaging Institute\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EThe University of Utah\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe motility and proliferation of angiogenic neovessels are modulated by the material properties of the extracellular matrix (ECM).\u0026nbsp; Neovessels also modify the material properties of the ECM as they migrate through and interact with the ECM.\u0026nbsp; This creates a dynamic feedback loop in which angiogenesis is coupled with deformation and remodeling of the ECM.\u0026nbsp; In this talk, he will discuss their experimental and computational research to investigate this phenomenon.\u0026nbsp; The experimental aspects of the research are based on a 3D in vitro organ culture model of sprouting angiogenesis.\u0026nbsp; The computational approach is based on coupling a validated model of angiogenic growth with the FEBio finite element software framework developed in their laboratory (\u003Ca href=\u0022http:\/\/www.febio.org\u0022 title=\u0022www.febio.org\u0022\u003Ewww.febio.org\u003C\/a\u003E).\u0026nbsp; In these studies they demonstrate that angiogenic neovessels extensively deform and remodel the ECM through a combination of cellular traction forces, proteolytic activity and generation of new cell-matrix adhesions.\u0026nbsp; Sensitivity analysis using their computational model demonstrated that cell-generated traction during growth is the most important parameter controlling the deformation of the matrix and therefore angiogenic growth, remodeling and morphometry of the resulting microvascular bed.\u0026nbsp; Live, large-scale mulitphoton imaging elucidated several neovessel behaviors during angiogenesis that are poorly understood such as episodic growth\/regression, neovessel co-location, and anastomosis.\u0026nbsp; The combined approach has allowed them to demonstrate that angiogenic growth and the resulting topology of a vascular network can be manipulated directly by altering the mechanical interactions between cells and the ECM.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between the Petit Institute and the Biomedical Engineering department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute, room 1128, unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Interaction of Angiogenic Microvessels with the Extracellular Matrix - Jeffrey A. Weiss, PhD - The University of Utah"}],"uid":"27959","created_gmt":"2014-11-14 17:58:55","changed_gmt":"2017-04-13 21:21:06","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-14T12:00:00-04:00","event_time_end":"2015-04-14T13:00:00-04:00","event_time_end_last":"2015-04-14T13:00:00-04:00","gmt_time_start":"2015-04-14 16:00:00","gmt_time_end":"2015-04-14 17:00:00","gmt_time_end_last":"2015-04-14 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/www.bioen.utah.edu\/directory\/profile.php?userID=96","title":"Weiss lab website"},{"url":"http:\/\/petitinstitute.gatech.edu\/bioe-seminars","title":"Bioengineering Seminar Series website"},{"url":"http:\/\/petitinstitute.gatech.edu\/","title":"Petit Institute website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"1808","name":"graduate students"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host:\u0026nbsp; \u003Ca href=\u0022mailto:robert.guldberg@me.gatech.edu\u0022\u003EBob Guldberg\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}