{"366741":{"#nid":"366741","#data":{"type":"event","title":"PhD Proposal Presentaion - Timothy Chang","body":[{"value":"\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003EProtein Nanoparticle Vaccines\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003EThesis Committee Members\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E Julie A. Champion, Ph.D. - School of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EJennifer K. Leavey, Ph.D. - School of Biology, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EKrishnendu Roy, Ph.D. - Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EMark R. Prausnitz, Ph.D. - School of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EBao-Zhong Wang, Ph.D. - Department of Microbiology and Immunology, Emory University School of Medicine\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EHighly conserved pathogen proteins are essential for broadly cross-protective vaccines, but tend to be poorly immunogenic. Protein nanoparticle vaccines made from conserved influenza matrix protein 2 and hemagglutinin trigger specific, adaptive immune responses that soluble protein cannot. Without excipients or adjuvants, protein nanoparticles eliminate the possibility of off-target immune responses, and their abiotic nature makes them amenable to cold chain-independent storage and use. The mechanisms by which protein nanoparticles enhance component protein immunogenicity are still not well understood. Protein nanoparticles will be made from hen egg ovalbumin and influenza proteins to examine dendritic cell responses in vitro and adaptive immune responses in vivo. The goals of this project are two-fold: to understand the immunological basis behind protein nanoparticle adjuvancy, and to improve this adjuvancy with studies into nanoparticle stability, enhancing endosomal buffering, and molecular adjuvants as nanoparticle coatings. This project aims to assess the viability of protein nanoparticles as a vaccine delivery platform.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation -\u0026nbsp;\u0022Protein Nanoparticle Vaccines\u0022 -\u0026nbsp;Timothy Chang\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Protein Nanoparticle Vaccines\u0022"}],"uid":"27349","created_gmt":"2015-01-22 10:22:16","changed_gmt":"2017-04-13 21:20:33","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-02-02T12:00:00-05:00","event_time_end":"2015-02-02T14:00:00-05:00","event_time_end_last":"2015-02-02T14:00:00-05:00","gmt_time_start":"2015-02-02 17:00:00","gmt_time_end":"2015-02-02 19:00:00","gmt_time_end_last":"2015-02-02 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"13974","name":"BioE Program events"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}