{"370261":{"#nid":"370261","#data":{"type":"event","title":"Emergent Behaviors of Integrated Cellular Systems Distinguished Lecture","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u201cIntegration of Actin Dynamics \u0026amp; Cell Adhesion by a Three-dimensional, Mechanosensitive Molecular Clutch\u201d\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003EClare M. Waterman, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ENIH Distinguished Investigator\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ELaboratory of Cell \u0026amp; Tissue Morphodynamics\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ENational Heart, Lung \u0026amp; Blood Institute\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003EForces generated in the actin cytoskeleton are transmitted across transmembrane receptors to the extracellular matrix (ECM) or other cells during directed migration. Force transmission from the cytoskeleton to the receptors is mediated by a series of mechanosensitive regulatable, indirect protein-protein interactions termed the \u201cmolecular clutch.\u201d In integrin-based focal adhesions, the proteins making up this linkage are organized into a conserved three-dimensional nano-architecture. Molecular clutches of similar architecture likely mediate cell adhesive interactions during tissue morphogenesis, the immune response, and vascular function.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBiography\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EClare Waterman graduated from the Mount Holyoke college with a B.A. in biochemistry in 1989, received an M.S. in exercise science in 1991 from the University of Massachusetts, and received her Ph.D. in cell biology from the University of Pennsylvania in 1995. Prior to joining the NHLBI, she spent 9 years as a professor in the Department of Cell Biology at the Scripps Research Institute in La Jolla, CA. Dr. Waterman is a NIH Distinguished Investigator and has received numerous awards and honors for her work, including the Arthur S. Flemming Award for Public Service (Basic Science) from George Washington University. Dr. Waterman has made fundamental advances in the understanding of cytoskeletal interactions and has authored or coauthored more than 90 papers. She currently serves on the editorial boards of Current Biology and Journal of Microscopy. Dr. Waterman is a member of the American Society for Cell Biology, Royal Microscopical Society, Biophysical Society, and is a Council Member of Gordon Research Conferences Organization.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.ebics.net\u0022\u003EEmergent Behaviors of Integrated Cellular Systems (EBICS)\u003C\/a\u003E is a National Science Foundation and Technology Center.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EEmergent Behaviors of Integrated Cellular Systems Distinguished Lecture -\u0026nbsp;\u201cIntegration of Actin Dynamics \u0026amp; Cell Adhesion by a Three-dimensional, Mechanosensitive Molecular Clutch\u201d - Clare M. Waterman, PhD - National Heart, Lung, and Blood Institute\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cIntegration of Actin Dynamics \u0026 Cell Adhesion by a Three-dimensional, Mechanosensitive Molecular Clutch\u201d - Clare M. Waterman, PhD - National Heart, Lung, and Blood Institute"}],"uid":"27195","created_gmt":"2015-01-29 15:50:10","changed_gmt":"2017-04-13 21:20:23","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-02-17T15:00:00-05:00","event_time_end":"2015-02-17T16:00:00-05:00","event_time_end_last":"2015-02-17T16:00:00-05:00","gmt_time_start":"2015-02-17 20:00:00","gmt_time_end":"2015-02-17 21:00:00","gmt_time_end_last":"2015-02-17 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"370241":{"id":"370241","type":"image","title":"Emergent Behaviors of Integrated Cellular Systems","body":null,"created":"1449245856","gmt_created":"2015-12-04 16:17:36","changed":"1475894344","gmt_changed":"2016-10-08 02:39:04","alt":"Emergent Behaviors of Integrated Cellular Systems","file":{"fid":"74995","name":"ebics-logo-updated_02.png","image_path":"\/sites\/default\/files\/images\/ebics-logo-updated_02.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/ebics-logo-updated_02.png","mime":"image\/png","size":6740,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/ebics-logo-updated_02.png?itok=zyD2qym1"}}},"media_ids":["370241"],"related_links":[{"url":"http:\/\/www.nhlbi.nih.gov\/research\/intramural\/researchers\/pi\/waterman-clare","title":"Waterman profile"},{"url":"http:\/\/www.ebics.net\/","title":"EBICS"}],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"},{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:sara.kunicki@me.gatech.edu\u0022\u003ESara Kunicki\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}