{"384441":{"#nid":"384441","#data":{"type":"event","title":"PhD Defense Presentation- Ivana Parker","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EIvana Parker\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EBioEngineering PhD Defense Presentation\u003C\/p\u003E\u003Cp\u003EMarch 19, 2015, 3:00 pm\u003C\/p\u003E\u003Cp\u003ESuddath Room, IBB\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAdvisor: Manu Platt, Ph.D.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThesis Committee Members:\u003C\/p\u003E\u003Cp\u003ERudy Gleason, Ph.D.\u003C\/p\u003E\u003Cp\u003ESuzanne Eskin, Ph.D.\u003C\/p\u003E\u003Cp\u003EW. Robert Taylor, Ph.D.\u003C\/p\u003E\u003Cp\u003ERoy Sutliff, Ph.D.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETitle: The Role of HIV-1 Tat and Antiretrovirals on Cathepsin Mediated Arterial Remodeling\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMajor advances in highly active antiretroviral therapies (ARVs) have extended the lives of people living with HIV, but there still remains an increased risk of death by cardiovascular diseases (CVD). HIV proteins and ARVs have been shown to contribute to cardiovascular dysfunction with effects on the different cell types that comprise the arterial wall. In particular, HIV-1 transactivating factor, Tat, is a cationic polypeptide that binds to endothelial cells, inducing a range of responses that have been shown to contribute to vascular dysfunction. It is well established that hemodynamics also play an important role in endothelial cell mediated atherosclerotic development where upon exposure to low or oscillatory shear stress, such as that found at branches and bifurcations, endothelial cells contribute to proteolytic vascular remodeling, by upregulating cathepsins, potent elastases and collagenases. Mechanisms to understand the influence of HIV proteins on shear mediated vascular remodeling have not been fully elucidated.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe objective of this thesis is to explore the effects of pro-atherogenic shear stress, HIV proteins, and antiretroviral therapies on the vasculature using in vivo and in vitro models. The goals are to determine the effects of pro-atherogenic shear stress conditions coupled with these HIV factors on proteolytic activity\u0026nbsp; and determine downstream regulatory mechanisms using in vitro culture systems and the HIV-transgenic mouse model.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022The Role of HIV-1 Tat and Antiretrovirals on Cathepsin Mediated Arterial Remodeling\u0022- Ivana Parker\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022The Role of HIV-1 Tat and Antiretrovirals on Cathepsin Mediated Arterial Remodeling\u0022"}],"uid":"27917","created_gmt":"2015-03-04 16:43:43","changed_gmt":"2017-04-13 21:19:52","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-19T16:00:00-04:00","event_time_end":"2015-03-19T18:00:00-04:00","event_time_end_last":"2015-03-19T18:00:00-04:00","gmt_time_start":"2015-03-19 20:00:00","gmt_time_end":"2015-03-19 22:00:00","gmt_time_end_last":"2015-03-19 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/platt.gatech.edu\/","title":"Platt Lab Website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}