{"404881":{"#nid":"404881","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Multiscale Patient-specific Systems Biology\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EScott L. Diamond, Ph.D.\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Chemical and Biomolecular Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EInstitute for Medicine and Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversity of Pennsylvania\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EPredicting tissue function based upon an individual\u2019s unique cells requires a multiscale Systems Biology approach to understand the coupling of intracellular signaling with spatiotemporal gradients of extracellular biochemicals.\u0026nbsp; Hundreds of spatiotemporal reactions proceed within activating platelets and the polymerizing plasma when blood clots under flow.\u0026nbsp; Clinically, excessive bleeding and clotting represent the two extremes of blood function that often concern patients and their doctors. Using high throughput experimentation, they obtained a large set of platelet responses to combinatorial activators in order to train a neural network (NN) model of platelet activation for several individuals. Each NN model was then embedded into a kinetic Monte Carlo\/finite element\/lattice Boltzmann simulation of stochastic platelet deposition under flow.\u0026nbsp; In silico representations of an individual\u2019s platelet phenotype allowed prediction of blood function under flow (as measured using microfluidics), essential to prioritizing patient-specific cardiovascular risk and drug response or to identify unsuspected gene mutations.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between the Petit Institute and the Biomedical Engineering department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute, Room 1128, unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Multiscale Patient-specific Systems Biology\u0022 - Scott L. Diamond, Ph.D. - University of Pennsylvania"}],"uid":"27959","created_gmt":"2015-05-15 11:39:35","changed_gmt":"2017-04-13 21:19:18","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-09-03T12:00:00-04:00","event_time_end":"2015-09-03T13:00:00-04:00","event_time_end_last":"2015-09-03T13:00:00-04:00","gmt_time_start":"2015-09-03 16:00:00","gmt_time_end":"2015-09-03 17:00:00","gmt_time_end_last":"2015-09-03 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.seas.upenn.edu\/~diamond\/index.html","title":"Diamond lab website"},{"url":"http:\/\/petitinstitute.gatech.edu\/bioe-seminars","title":"Bioengineering Seminar Series website"},{"url":"http:\/\/petitinstitute.gatech.edu\/","title":"Petit Institute website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"126221","name":"go-immuno"},{"id":"1808","name":"graduate students"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host:\u0026nbsp; \u003Ca href=\u0022mailto:hang.lu@gatech.edu\u0022\u003EHang Lu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}