{"428981":{"#nid":"428981","#data":{"type":"event","title":"PhD Defense by Caitlin Martin","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ECaitlin Martin\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EPhD\u0026nbsp;Defense\u0026nbsp;Presentation\u003Cbr \/\u003E Date: Tuesday August 11th, 2015\u003C\/p\u003E\u003Cp\u003ETime: 2:00pm\u003C\/p\u003E\u003Cp\u003ELocation: TEP 104\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThesis\u0026nbsp;committee\u0026nbsp;members:\u003C\/p\u003E\u003Cp\u003EAdvisor: Wei Sun, Ph.D. (BME)\u003Cbr \/\u003E John Elefteriades, M.D. (Yale)\u003Cbr \/\u003E Ajit Yoganathan, Ph.D. (BME)\u003Cbr \/\u003E Gang Bao, Ph.D. (ME)\u003Cbr \/\u003E Muralidhar Padala, Ph.D. (Emory)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E \u003Cstrong\u003ETitle:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EModeling and simulation of time-dependent inelastic soft tissue behavior.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E \u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EOver long periods of time, soft collagenous tissues undergo irreversible microstructural changes including elastin degradation and collagen fiber un-crimping owing in part to the natural aging process and mechanical fatigue damage.\u0026nbsp; These changes are accelerated in tissue-derived medical devices which lack regenerative repair abilities, and have deleterious effects on physiological function.\u0026nbsp; Methods to predict collagenous tissue property changes in response to various factors could facilitate the design of durable tissue-based devices and the development of enhanced diagnostic and preventative treatment methods.\u0026nbsp; However, most of the biomechanics work on soft collagenous tissues reported in the literature thus far, whether experimental, theoretical, or computational, is confined to static, instantaneous tissue property characterization.\u0026nbsp; As such, only the recoverable or elastic behavior of tissue is considered, although from a thermodynamics stand point, permanent changes in tissue structure and material properties represent dissipative, inelastic effects.\u0026nbsp; Thus, the objective of this thesis was to develop a theoretical and computational framework to describe the time-dependent inelastic behavior of soft tissues such that the effects of mechanical fatigue damage and aging in soft tissues could be accurately modeled.\u0026nbsp; The framework was implemented in a finite element solver and applied to investigate the effects of aging on the human ascending aorta, and the effects of leaflet fatigue damage in bioprosthetic heart valves.\u0026nbsp; The results from these studies may offer scientific rationale for the design of improved devices and diagnostic methods.\u003C\/p\u003E\u003Cp\u003E \u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Modeling and simulation of time-dependent inelastic soft tissue behavior"}],"uid":"27707","created_gmt":"2015-07-29 10:20:23","changed_gmt":"2016-10-08 02:12:37","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-08-11T15:00:00-04:00","event_time_end":"2015-08-11T17:00:00-04:00","event_time_end_last":"2015-08-11T17:00:00-04:00","gmt_time_start":"2015-08-11 19:00:00","gmt_time_end":"2015-08-11 21:00:00","gmt_time_end_last":"2015-08-11 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}