{"472821":{"#nid":"472821","#data":{"type":"event","title":"PhD Proposal Presentation - Kathleen Bates","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Hang Lu, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJennifer Curtis, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDaniel Goldman, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EPatrick McGrath, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ELe Song, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMark Styczynski, Ph.D.\u003C\/strong\u003E \u003Cstrong\u003E(\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EAn automated and low-cost microfluidic platform for behavioral phenotyping of \u003Cem\u003ECaenorhabditis elegans\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Animal behavior results from a multitude of factors, including external stimuli and internal neural state, as well as past experiences. Behavior is therefore highly variable and dependent on developmental trajectory. This plays clear roles in disease, including psychiatric disorders and diseases that span a continuum, such as autism spectrum disorder. At the same time, these disorders are partially heritable, and usually this heritability is multigenic. In order to address how genes and the environment interact to regulate variability, large-scale experiments with high repeatability are requisite. \u003Cem\u003ECaenorhabditis elegans\u003C\/em\u003E, a small roundworm, significantly simplifies genetic experiments through ease of isogenic culture.\u0026nbsp; However, no technology currently exists that can provide continuous temporal monitoring and behavioral analysis of \u003Cem\u003EC. elegans\u003C\/em\u003E for days-long timescales. In this thesis, a low-cost microscopy and analysis system will be developed to enable scalable implementation of a dynamically controlled microfluidic environment. A general-purpose behavior analysis system will be implemented to evaluate behavioral flexibility across biologically relevant physical and chemical environments. This same analysis technique will then be used to compare the behavior of a library of recombinant inbred \u003Cem\u003EC. elegans\u003C\/em\u003E lines, with the goal to map quantitative behavioral traits to a set of genetic loci and begin addressing the complex question of gene-environment interactions in relation to behavior. This system will also be useful for other large-scale behavioral applications, including drug screening and associative learning.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022An automated and low-cost microfluidic platform for behavioral phenotyping of Caenorhabditis elegans\u0022- Kathleen Bates\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022An automated and low-cost microfluidic platform for behavioral phenotyping of Caenorhabditis elegans\u0022"}],"uid":"27917","created_gmt":"2015-11-24 08:45:39","changed_gmt":"2017-04-13 21:17:34","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-12-07T13:30:00-05:00","event_time_end":"2015-12-07T15:30:00-05:00","event_time_end_last":"2015-12-07T15:30:00-05:00","gmt_time_start":"2015-12-07 18:30:00","gmt_time_end":"2015-12-07 20:30:00","gmt_time_end_last":"2015-12-07 20:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}