{"490931":{"#nid":"490931","#data":{"type":"event","title":"BioE PhD Proposal presentation- Rachel Simmons","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Hanjoong Jo, Ph.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMichael Davis, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECharles Searles Jr., M.D.\u003C\/strong\u003E\u0026nbsp;(Emory School of Medicine)\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ELoren Williams, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EYounan Xia, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EmiR-744 Modulation by Disturbed Flow and Role in Endothelial Dysfunction and Atherosclerosis\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;Atherosclerosis is the leading cause of death worldwide despite the use of cholesterol-lowering statins and anti-platelet drugs. The disease localizes to arterial regions exposed to disturbed flow due to the effect of low-magnitude and oscillating shear stress (OS) on endothelial gene expression. However, there are no treatment options to target hemodynamic-mediated mechanisms due to a lack of mechanistic understanding. \u003Cstrong\u003EThe objective of this proposal is to elucidate the effects of d-flow-induced miRNAs on endothelial gene expression and the mechanisms initiating endothelial dysfunction and atherosclerosis.\u003C\/strong\u003E Recently, our lab reported that miR-663 is highly upregulated by OS in human endothelial cells and potentially induces endothelial inflammation. Interestingly, preliminary studies indicate that another miR-663 family member, miR-744, which has a common seed sequence with miR-663, is also upregulated by OS, and may also induce inflammation. \u003Cstrong\u003ETherefore, the overall hypothesis is that overexpression of miR-744 by OS causes endothelial dysfunction and atherosclerosis.\u003C\/strong\u003E \u0026nbsp;To test the hypothesis, miR-744 modulation of OS-induced endothelial dysfunction will be assessed \u003Cem\u003Ein vitro\u003C\/em\u003E, the therapeutic effect of miR-744 inhibition on atherosclerosis development will be assessed \u003Cem\u003Ein vivo\u003C\/em\u003E, and relevant direct targets will be determined.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0022miR-744 Modulation by Disturbed Flow and Role in Endothelial Dysfunction and Atherosclerosis\u0022- Rachel Simmons\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022miR-744 Modulation by Disturbed Flow and Role in Endothelial Dysfunction and Atherosclerosis\u0022"}],"uid":"27917","created_gmt":"2016-01-26 14:17:47","changed_gmt":"2017-04-13 21:16:56","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-02-18T09:00:00-05:00","event_time_end":"2016-02-18T11:00:00-05:00","event_time_end_last":"2016-02-18T11:00:00-05:00","gmt_time_start":"2016-02-18 14:00:00","gmt_time_end":"2016-02-18 16:00:00","gmt_time_end_last":"2016-02-18 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}