One strategy is based on the phenomenon of collateral sensitivity: When some microbes develop resistance to one antibiotic, they become hypersensitive to another. For example, when an Escherichia coli strain became indifferent to chloramphenicol, it also became highly vulnerable to polymyxin B. For this strain, chloramphenicol and polymyxin B form a collaterally sensitive pair.
Sometimes the drug pair exhibits mutual collateral sensitivity (MCS) for a pathogen: The pathogen’s evolution of resistance to drug A increases its sensitivity to drug B and vice versa.
Researchers have identified several MCS pairs for pathogens like E. coli and Pseudomonas aeruginosa. Some have proposed exploiting the phenomenon to treat infections by cycling through the drugs, A-B-A-B.
“This sounds very clever,” says Georgia Tech biomathematician Howard “Howie” Weiss. “Bbut what could prevent this scheme from working is the rapid emergence and ascent of a population of cells that are resistant to both antibiotics.”
The prospect is exciting, but no experiments have yet been performed to test efficacy.
“This was a real team effort between a microbiologist and a biomathematician.”
With Stockholm University microbiologist Klas Udekwu, Weiss has tested the plausibility of such schemes, using a mathematical model that considers factors affecting efficacy. Applying treatment protocols consisting of pairs MCS antibiotics, they examined how fast multiply-resistant mutants would emerge. They reported results in Drug Design, Development and Therapy.
They found some treatments that did not produce multiply-resistant mutants for several weeks, for several months, and even indefinitely. That means some combinations of an MCS pair prevented further development of the bacteria’s resistance to either drug.
“This was a real team effort between a microbiologist and a biomathematician,” Weiss says. “My job was to construct the model using a system of differential equations and very carefully simulate their solution using a computer.”
The first experiment used low to moderate concentrations of antibiotics and daily cycling: drug A on day 1, drug B on day 2, drug A on day 3. At these drug levels, treatment failed. Resistant mutants rapidly developed and dominated.
Simulation results improved with higher drug concentrations. “We found that one-day cycling of certain antibiotics kept the double-resistant mutants in check for over two weeks, which would be sufficient to cure many infections,” Weiss says.
The simulations also showed that three-day cycling of antibiotics that only inhibit bacterial growth – not kill – would never result in double-resistant mutants. “This was striking,” Udekwu says, “but in line with ecological theory.”
Udekwu is now conducting in-vitro cycling experiments. The next step would likely be experiments in mice. “It is far too early for clinicians to think about this strategy,” he says, “other than to keep an ear out for it, perhaps in a Cochrane report someday.
]]>Using a mathematical model, Georgia Tech biomathematician Howard “Howie” Weiss and Stockholm University microbiologist Klas Udekwu open a potential path to slowing microbial resistance to current antibiotics.
Using a mathematical model, Georgia Tech biomathematician Howard “Howie” Weiss and Stockholm University microbiologist Klas Udekwu open a potential path to slowing microbial resistance to current antibiotics.
The fellowships are made possible by a generous gift to the College of Sciences from alumni Frank H. Cullen (B.S. in Mathematics with Honors 1973, M.S. in Operations Research 1975, Ph.D. Engineering 1984) and Libby Peck (B.S. in Applied Mathematics 1975, M.S. in Industrial Engineering 1976). The alumni couple wish to recognize and support faculty development in the College of Sciences
“We continue to be grateful for the generosity of alumni who encourage our faculty to take intellectual risks in their research,” says College of Sciences Dean and Sutherland Chair Paul M. Goldbart. “The Cullen-Peck fellowships help ensure that our research is pushing the frontiers of knowledge. Congratulations to the latest Cullen-Peck fellows.”
Knot Theory
Jennifer C. Hom is an associate professor in the School of Mathematics. The award recognizes her outstanding research in knot theory, which has led to fundamental contributions to the study of knots and development of powerful tools in topology.
Knots can be conceived as loops of strings with ends glued together. Their study is a beautiful subject, central to understanding low-dimensional space, as well as some modern trends in physics. Hom’s work centers on knots in three-dimensional space. She has enriched the field by introducing deep new ideas.
A much-studied question asks whether a knot can bound a disk in four-dimensional space in certain nice ways. Such knots were previously known. But Hom was able to find a huge new family of such knots, inspiring a flurry of activity in the use of Heegaard-Floer theory to study such objects.
The Heegard-Floer theory is a much-studied technique that revolutionized low-dimensional topology. Yet, Hom found new subtle features, which she formalized as the epsilon invariant. The epsilon invariant is a number associated to each knot. By using the properties of these numbers, Hom proved that an infinite number of knots could bound certain disks in four-dimensional space and not others.
Her work inspired leaders in the field, including the developers of Heegaard-Floer theory themselves, to pursue new avenues of research. Among other things, this work gives a new proof that in a sense there is more than one way to do calculus in four dimensions.
The epsilon invariant is now part of the Heegard-Floer theory; it is taught in graduate courses around the world; it is considered one of the top five spectacular advances in the past decade. A mark of top-notch mathematics is that it inspires other people and takes a life of its own. Hom’s epsilon invariant belongs to this category.
“It's a great honor to receive this award,” Hom says. “I look forward to using this fellowship to help develop new techniques for studying knots and low-dimensional spaces.”
Biogeochemical Cycling and Ocean Deoxygenation
Takamitsu “Taka” Ito is an associate professor in the School of Earth and Atmospheric Sciences. The Cullen-Peck award recognizes his outstanding research in biogeochemical cycling and ocean deoxygenation.
Ito uses models to better understand the interactions of physical, chemical, and biological processes that regulate the cycling of chemical elements in the ocean. He develops theories of the partitioning of dissolved gases between the ocean and the atmosphere. He is renowned for recent work on the distribution of dissolved oxygen in the subsurface ocean.
In the 2017 paper “The Upper Ocean Oxygen Trend: 1958-2015,” Ito analyzed historical, global datasets of dissolved oxygen. He found that the amount of dissolved oxygen in the water – an important measure of ocean health – has been declining for more than 20 years.
This paper garnered media attention for the implications of declining oxygen in the ocean: It could affect the habitat of marine organisms worldwide. It could lead to more frequent “hypoxic events,” which kill or displace populations of fish, crabs, and other organisms.
Furthermore, the analysis showed that ocean oxygen is falling more rapidly than anticipated from the rise in water temperature due to climate change.
Ito has also been exploring the previously under-appreciated role of polluted aerosols in altering ocean biogeochemistry. In a 2016 paper in Nature Geoscience, he and his collaborators showed that air pollution can deliver additional iron and reactive nitrogen to the ocean and affect oxygen levels.
The transport of highly insoluble iron to the ocean and its availability for biological productivity are not well understood. Ito’s modelling approach will help translate into new insights the oceanic iron data from the large observational program GEOTRACES. His research could reveal how iron cycling affects ocean productivity, carbon uptake, and oxygen concentrations over various time scales.
Cognitive Neuroscience of Aging
Scott Moffat is an associate professor in the School of Psychology. His selection as Cullen-Peck fellow is based on his outstanding research in the cognitive neuroscience of aging.
With aging comes cognitive decline, which affect mental faculties including memory and the ability to navigate. Moffat has embarked on research addressing metabolism and aging. In particular, he studies the role of diabetes in cognitive aging.
Peripheral insulin crosses the blood–brain barrier to modulate memory processes. Insulin resistance in the periphery goes with insulin resistance in the brain and memory impairment. The hope is to associate variations in peripheral insulin secretion and insulin sensitivity to cognitive and neural endpoints.
Meanwhile, type 2 diabetes is a public health crisis in the U.S. and many developed countries. The disease is a risk factor for other serious health conditions, such as brain and cognitive dysfunction, as well as Alzheimer’s disease. Using functional magnetic resonance imaging, Moffat is examining the association of glucose and insulin metabolism with cognitive and brain function.
The research is still in its early days, but already Moffat and his colleagues are realizing remarkable results. For example, they’ve found that individuals with higher fasting glucose levels or insulin insensitivity – even within the non-diabetes range – have poorer performance in episodic and working memories. They also have thinner gray matter in key prefrontal cortical areas.
The implications for prediabetes are profound. Prediabetes is prevalent among adults; the National Center for Chronic Disease Prevention reports that majority of all adults older than 65 have prediabetes. Discovering the impact of prediabetes on cognition and cognitive decline could bring about interventions, pharmaceutical or otherwise.
]]>Time: Wednesday, September 5, 2018 - 4:00pm to 5:00pm
Location: Suddath Seminar Room at the Petit Institute, 315 Ferst Drive, Rm. 1128
Organizers: Professors Jeff Wu, Santanu Dey, and Xiaoming Huo (ISyE)
Bio: David Leigh Donoho is a professor of statistics at Stanford University, where he is also the Anne T. and Robert M. Bass Professor in the Humanities and Sciences. His work includes the development of effective methods for the construction of low-dimensional representations for high-dimensional data problems (multiscale geometric analysis), developments of wavelets for denoising and compressed sensing.
In 1991, Donoho was named a MacArthur Fellow. He was elected a Fellow of the American Academy of Arts and Sciences in 1992. He was the winner of the COPSS Presidents' Award in 1994. In 2001, he won the John von Neumann Prize of the Society for Industrial and Applied Mathematics. In 2002, he was appointed to the Bass professorship. He was elected a SIAM Fellow and a foreign associate of the French Académie des sciences in 2009, and in the same year received an honorary doctorate from the University of Chicago. In 2010 he won the Norbert Wiener Prize in Applied Mathematics, given jointly by SIAM and the American Mathematical Society. He is also a member of the United States National Academy of Science. In 2012 he became a fellow of the American Mathematical Society. In 2013 he was awarded the Shaw Prize for Mathematics. In 2016, he was awarded an honorary degree at the University of Waterloo.
More details on this event will be posted at https://www.isye.gatech.edu/news-events/events/calendar/day/9773 and http://triad.gatech.edu/events.
]]>School of Mathematics faculty members Igor Belegradek, John Etnyre, Stavros Garoufalidis, Mohammad Ghomi, Jennifer Hom, Thang Le, Dan Margalit, and Kirsten Wickelgren make up GTGT and are co-principal investigators of the grant.
Why Study Topology and Geometry
Etnyre answers this question. He explains:
“Topology is the study of spaces. They can be the space we live in or configurations of mechanical systems. Mathematicians also consider spaces of solutions to algebraic equations and partial differential equations, as well as even more abstract space.
“More specifically topology is the study of spaces where some notion of continuity makes sense. What are these spaces? How can we distinguish one space from another? What interesting properties do specific spaces have? These are the basics questions in topology, whose language pervades much of mathematics, science, and engineering.
“Geometry is, loosely speaking, the study of some kind of structure on a space. Riemannian geometry involves spaces on which you can measure lengths of vectors and the angles in between. Symplectic geometry allows one to study dynamical systems akin to classical mechanics on a space.
“Topology and geometry underlie a great deal of science and engineering. Whether trying to understand general relativity and the structure of the universe, design robust sensor networks, unravel DNA recombination, develop string theory, or countless other endeavors, the underlying language and ideas are likely to be that of geometry and topology.”
“Topology and geometry underlie a great deal of science and engineering. Whether trying to understand general relativity and the structure of the universe, design robust sensor networks, unravel DNA recombination, develop string theory, or countless other endeavors, the underlying language and ideas are likely to be that of geometry and topology.”
Expected Outcomes
Over its five-year run, the grant will enable the training of 60 undergraduate students, 22 graduate students, and 14 postdoctoral fellows. Supplementary funding from the College of Sciences will ensure three years of support for all postdoctoral fellows.
Etnyre says GTGT will leverage its access to Georgia Tech’s engineering programs to spark collaborations between engineers and mathematicians. Similarly, GTGT will use its proximity to institutions serving groups underrepresented in mathematics to help increase the representation of minorities and women in advanced mathematics.
Ultimately, Etnyre says, “we aim to develop students and postdoctoral fellows who are well-rounded scholars, accomplished teachers, and valuable members of the mathematics community.”
Areas of Expertise
The GTGT group is strong in various fields:
All these areas would benefit from the grant.
“We aim to develop students and postdoctoral fellows who are well-rounded scholars, accomplished teachers, and valuable members of the mathematics community.”
Grant-Enabled Activities
The grant enables the GTGT group to embark on several major activities:
School of Mathematics faculty will use the grant to provide comprehensive training through fellowships, expanded courses, seminars, conferences, and professional development activities.
]]>The School of Mathematics likely takes the prize for the most number of programs by one unit: six. By summer’s end, seven professors, three postdoctoral mentors, and five graduate students would have worked with 13 undergraduate students. The undergrads come from 11 colleges and universities, including three in Georgia: Agnes Scott College, Georgia Tech, and Spelman College.
Funding comes from various NSF grants and the School of Mathematics.
Why REUs
REU programs play the same role for research careers as high school sports do for the NFL and NBA, says School of Mathematics Professor Igor Belegradek. Talent presenting early must be nurtured and honed as soon as possible.
Belegradek organized the summer 2018 REUs with colleague Dan Margalit.
“We have a rich history of undergraduate research in mathematics, as you can see on our website,” Margalit says. “It’s a testament to our faculty’s intellectual creativity and dedication to undergraduate education.”
REUs have important benefits for students, faculty mentors, and the School of Mathematics.
They help bring students to the School’s graduate program. They enable members of underrepresented minorities get advanced training and positive experiences in math research.
REUs advance the research of faculty. “We give students problems that we are genuinely interested in,” Margalit. “They are integral to our research programs.”
REUs also provide mentoring experience to early-career researchers – graduate students and postdoctoral researchers – serving as mentors. “The training is valuable for them,” Margalit says. “It helps give them confidence in their own research and make them marketable for job searches.”
Undergraduates’ ability to penetrate difficult problems inspires Margalit. “They are fearless and creative, trying approaches that I might not think of,” he says. “They might not understand every bit of background that goes into a problem. But we, as mentors, can airlift them to the front lines of the problem.”
Undergraduates "are fearless and creative, trying approaches that I might not think of. They might not understand every bit of background that goes into a problem. But we, as mentors, can airlift them to the front lines of the problem." Dan Margalit
Cutting-Edge Research
Although Margalit’s program – on mapping class groups – has six students, other REUs have only one or two students. Three began as early as May 21; one will last until Aug. 10. In sessions lasting from five to seven weeks, the mathematicians will tackle problems in various cutting-edge areas.
Following are two examples of problems Georgia Tech undergrads will be confronting.
Mohammad Ghomi has been working with Georgia Tech undergraduate Alexander Avery since May 21. From Ghomi’s list of open problems in geometry of curves and surfaces, Avery chose the “shadow problem” for surfaces.
Ghomi explains the problem thus: Consider a convex object, such as a ball or an egg. When such object is illuminated from any direction, the dark region of the surface, called the shadow, forms a connected set. In other words, the shadow is one piece.
What about the converse? Suppose the shape of a surface is unknown. And suppose the shadow is one piece when illuminated from any direction. Does it follow that the surface is convex?
Ghomi published a solution in Annals of Mathematics in 2002. The answer is yes for surfaces similar to balls and eggs. But not for other shapes, such as donuts.
“Alex is working on the discrete version of this problem,” Ghomi says. Avery is looking at surfaces that are not smooth – like balls and eggs – but instead are composed of polygons glued along their edges. “Alex has been making good progress. It looks like the polyhedral case will be similar to the smooth case.”
“In mathematics, knots can be thought of as pieces of string which are tied up and then have the ends glued together,” says Caitlin Leverson, one of the postdoctoral mentors. “An interesting problem is to decide whether two knots are the same or different.”
Legendrian knots satisfy additional conditions. Two Legendrian knots may look very different, but be the same. Invariants are methods of assigning values to knots so that two knots are assigned the same value if they are the same.
From May 29 to Aug. 10, Leverson will be working with two Georgia Tech fourth-year mathematics majors: DeVon Ingram and Hunter Vallejos. Their goal is to find Legendrian knots that are different yet are assigned the same value by the invariant.
Since his second year as a mathematics major, Ingram has done research with different professors, including outside the School of Mathematics. For example, he worked on computational complexity theory with Lance Fortnow, professor and chair, School of Computer Science.
Ingram appreciates the beauty of differential geometry and its relation to physics. He sees correspondence between knot invariants and topological quantum field theories. Because of these interests, “I am naturally drawn to a knot theory problem,” he says.
Vallejos has been doing research since he was in Oak Ridge High School, in Oak Ridge, Tennessee, just 10 miles from Oak Ridge National Laboratory (ORNL). One outcome of his stints at ORNL is a 2017 paper in the Journal of Economic Interaction and Coordination, of which Vallejos was first author.
“I love when algebra, geometry, and topology intersect,” Vallejos says. “Legendrian knot theory blends these three distinct fields, which makes it a rich subject to study.”
Visiting Students
Several of the undergraduate researchers this summer come from outside Georgia Tech. Among them are Johannes Hosle and Andrew Sack.
Johannes Hosle hails from South Bend, Indiana. He is a third-year math major in the University of California, Los Angeles. His major interests are analysis and number theory. Starting on June 18, he will work with Galyna Livshyts and Michael Lacey.
“The general area of my problem will be in harmonic analysis in convex geometry,” Hosle says. “My interest stems from a general interest in analysis. The types of problems in this branch of mathematics seem to resonate most with me.”
Andrew Sack hails from Gainesville, Florida. He is a fourth-year mathematics major from the University of Florida. A published author in the International Journal of Mathematics and Computer Science, he is one of two students who have been working with John Etnyre and Sudipta Kolay since May 30.
Etnyre also studies how to tell knots apart. In his approach, a knot is represented by a diagram of a loop on a paper. The loop can cross over itself as many times. “But each time the loop crosses over itself, you have to specify which of the two strands is on top of the other,” Etnyre says.
A coloring of a knot is a labeling of the strands by a method that has consistency at the crossings. The coloring can tell two knots apart. “The work is related to research trying to figure out how three-dimensional spaces can be put inside a five-dimensional space.”
“I’m interested in this research because, after taking two years of topology, I find it fascinating,” Sack says. “Previous research I’ve done centered on graph coloring. I can use some of the intuition I built around graph coloring to help better understand knot coloring.”
This story was modified from a story appearing June 14th by Maureen Rohi.
]]>This summer, the School of Mathematics continues its rich history of undergraduate research, which testifies to faculty’s intellectual creativity and dedication to undergraduate education.
]]>According to a new study, the answer is the microbiome – the community of bacteria found in homes, offices and aircraft cabins. Believed to be the first to comprehensively assess the microbiome of aircraft, the study found that the bacterial communities accompanying airline passengers at 30,000 feet have much in common with the bacterial communities surrounding people in their homes and offices.
Using advanced sequencing technology, researchers from the Georgia Institute of Technology and Emory University studied the bacteria found on three components of an airliner cabin that are commonly touched by passengers: tray tables, seat belt buckles and the handles of lavatory doors. They swabbed those items before and after ten transcontinental flights and also sampled air in the rear of the cabin during flight.
What they found was surprisingly unexciting.
“Airline passengers should not be frightened by sensational stories about germs on a plane,” said Vicki Stover Hertzberg, a professor in Emory University’s Nell Hodgson Woodruff School of Nursing and a co-author of the study. “They should recognize that microbes are everywhere and that an airplane is no better and no worse than an office building, a subway car, home or a classroom. These environments all have microbiomes that look like places occupied by people.”
The results of the FlyHealthy™ study were reported June 6, 2018, in the journal Microbial Ecology. In March, the researchers reported on a separate part of the study that examined potential routes for transmitting certain respiratory viruses – such as the flu – on commercial flights.
Given the unusual nature of an aircraft cabin, the researchers hadn’t known what to expect from their microbiome study. On transcontinental flights, passengers spend four or five hours in close proximity breathing a very dry mix of outdoor air and recycled cabin air that has been passed through special filters, similar to those found in operating rooms.
“There were reasons to believe that the communities of bacteria in an aircraft cabin might be different from those in other parts of the built environment, so it surprised me that what we found was very similar to what other researchers have found in homes and offices,” said Howard Weiss, a professor in Georgia Tech’s School of Mathematics and the study’s corresponding author. “What we found was bacterial communities that were mostly derived from human skin, the human mouth – and some environmental bacteria.”
The sampling found significant variations from flight to flight, which is consistent with the differences other researchers have found among the cars of passenger trains, Weiss noted. Each aircraft seemed to have its own microbiome, but the researchers did not detect statistically significant differences between preflight and post-flight conditions on the flights studied.
“We identified a core airplane microbiome – the genera that were present in every sample we studied,” Weiss added. The core microbiome included genera Propionibacterium, Burkholderia, Staphylococcus, and Strepococcus (oralis).
Though the study revealed bacteria common to other parts of the built environment, Weiss still suggests travelers exercise reasonable caution. “I carry a bottle of hand sanitizer in my computer bag whenever I travel,” said Weiss. “It’s a good practice to wash or sanitize your hands, avoid touching your face, and get a flu shot ever year.”
This new information on the aircraft microbiome provides a baseline for further study, and could lead to improved techniques for maintaining healthy aircraft.
“The finding that airplanes have their own unique microbiome should not be totally surprising since we have been exploring the unique microbiome of everything from humans to spacecraft to salt ponds in Australia. The study does have important implications for industrial cleaning and sterilization standards for airplanes,” said Christopher Dupont, another co-author and an associate professor in the Microbial and Environmental Genomics Department at the J. Craig Venter Institute, which provided bioinformatics analysis of the study’s data.
The 229 samples obtained from the aircraft cabin testing were subjected to 16S rRNA sequencing, which was done at the HudsonAlpha Institute for Biotechnology in Huntsville, Alabama. The small amount of genetic material captured on the swabs and air sampling limited the level of detail the testing could provide to identifying genera of bacteria, Weiss said. The extensive bioinformatics, or sequence analysis, was carried out at the J. Craig Venter Institute in La Jolla, Calif.
In the March 19 issue of the journal Proceedings of the National Academy of Sciences, the researchers reported on the results of another component of the FlyHealthy™ study that looked at potential transmission of respiratory viruses on aircraft. They found that an infectious passenger with influenza or other droplet-transmitted respiratory infection will most likely not transmit infection to passengers seated farther away than two seats laterally and one row in front or back on an aircraft.
That portion of the study was designed to assess rates and routes of possible infectious disease transmission during flights, using a model that combines estimated infectivity and patterns of contact among aircraft passengers and crew members to determine likelihood of infection. FlyHealthy™ team members were assigned to monitor specific areas of the passenger cabin, developing information about contacts between passengers as they moved around.
Among next steps, the researchers would like to study the microbiome of airport areas, especially the departure lounges where passengers congregate before boarding. They would also like to study long-haul international flights in which passengers spend more time together – and are more likely to move about the cabin.
In addition to those already mentioned, the paper’s authors include Josh L. Espinoza and Karen Nelson of the J. Craig Venter Institute, Shawn Levy of the HudsonAlpha Institute for Biotechnology, and Sharon Norris of The Boeing Company.
This work was supported by contract 2001-041-1 between the Georgia Institute of Technology and The Boeing Company.
CITATION: Howard Weiss, et al., “The Airplane Cabin Microbiome,” (Microbial Ecology, 2018). https://link.springer.com/article/10.1007/s00248-018-1191-3
Research News
Georgia Institute of Technology
177 North Avenue
Atlanta, Georgia 30332-0181 USA
Media Relations Contact: John Toon (404-894-6986) (jtoon@gatech.edu).
Writer: John Toon
]]>Research News
(404) 894-6986
]]>Students major in the College of Sciences because they’re curious about the natural world. They want to know why things are the way they are. They want to solve problems, to explain the mysteries of the universe, and to use science and technology to better people’s lives.
At the end of the Spring 2018 semester, 11 of those students received awards for outstanding achievements.
“We take great pleasure in recognizing and nurturing the outstanding, well-rounded students in our care,” says College of Sciences Dean and Sutherland Chair Paul M. Goldbart. “They are the reason we are constantly striving to strengthen and diversify the educational experiences and research opportunities that we offer.”
“I cannot say a more heartfelt thank you to the benefactors of these awards and scholarships,” Goldbart says. “Their generosity marvelously expands our ability to support deserving students and retain them in the College.”
Outstanding Undergraduate Researcher Award
This award recognizes undergraduates who are committed to research. Ann Johnson, a biology major, and Calvin Runnels, a biochemistry major, are the 2018 recipients in the College of Sciences.
Johnson is passionate about changing global health and interested in engineering for the developing world. She has conducted research with Joe Brown, in the School of Civil and Environmental Engineering, with Omer Inan, in the School of Electrical and Computer Engineering, and at Johns Hopkins University. “It’s so important to intersect an understanding of humanities and science in order to look at culture and how it impacts people,” Johnson says.
The intersection of science and people also fascinates Runnels. He conceived and implemented the Undergraduate Research Fair to connect labs with students. He tirelessly advocated for marginalized and LGBTQ students.
Runnels conducted research on the origins of protein folding in the lab of Loren Williams, in the School of Chemistry and Biochemistry. His work yielded a yet-unpublished manuscript about the nature of biopolymers of which he is the first author
Runnels graduated in May 2018 and is headed to Oxford University as a Rhodes Scholar. According to one professor, Runnels is “a once-in-a-decade student” who displays empathy as well as a command of science.
Gretzinger Undergraduate Research Initiation Award
The award focuses on students just getting started in research. The award seeks to early involvement and broaden the recipient’s participation in research. Keith Creech, a biochemistry major, is the 2018 recipient. He will begin research with Robert Dickson, in the School of Chemistry and Biochemistry, in summer 2019.
Mehta Phingbodhipakkiya Memorial Scholarship
The scholarship honors the top junior in the College of Sciences. Sara Brockmeier is the 2018 recipient. Brockmeier majors in psychology with a business option.
Brockmeier conducts research in the joint lab of Phillip Ackerman and Ruth Kanfer, also called the PARK Lab, in the School of Psychology. She studies the influence of factors affecting workplace learning, behavior, and performance. She helped pilot a study of test-retest reliability aptitude tests used by the U.S. Navy.
Brockmeier hopes to apply her research to a career in industrial and organizational psychology.
Larry O’Hara Graduate Scholarship
The award recognizes outstanding graduate students. The 2018 recipients are Joel Mumma and Jennifer Pentz.
Joel Mumma, a psychology Ph.D. student, also hopes to use psychology to improve people’s lives. Winning this award, he’s doing a bit more than hoping. Mumma has written a paper that will save lives, according to his advisor, Frank Durso.
Mumma led the risk analyses of protocols that health care providers follow to protect themselves from dangerous pathogens, such as Ebola. The paper, in Clinical Infectious Diseases, is filled with “a number of nuanced and surprising findings that tell us a little more about the psychology of human error,” Durso says. Hospitals are already putting to the results to practice. This paper, Durso adds, is just the beginning for this “rising star.”
Jennifer Pentz is a biology Ph.D. student. Using yeast cells, she studies the origins of multicellularity with William Ratcliff, in the School of Biological Sciences. It was during her undergraduate research at the University of Minnesota that Pentz discovered an interest in ecological and evolutionary questions.
At Tech, Pentz co-authored a study finding that physical stress may have been critical in the rise of multicellular organisms from single cells. Her work with yeast brought her to the Atlanta Science Festival, where she demonstrated the “Science of Beer”.
A. Joyce Nickelson and John C. Sutherland Undergraduate Research Award
Daniel Gurevich is the 2018 winner. The award recognizes excellence at the interface of mathematics and physics.
No stranger to solving real-world problems, Gurevich is interested in data analysis. An algorithm he developed has helped discover new mechanisms for ventricular fibrillation. This heart disorder is fatal within minutes if not treated. He also wants to be able to predict when patients in intensive care units might crash based on their vital signs.
An author of two research papers, Gurevich is triple majoring in physics, mathematics, and industrial and systems engineering. This broad perspective gives him an edge. He says it helps him find patterns in data.
Perhaps his love for problem solving comes from chess. He started playing at age five, and now he’s an International Master.
Roger M. Wartell and Stephen E. Brossette Award for Multidisciplinary Studies in Biology, Physics, and Mathematics
Being able to study more than one field – and to synthesize them – is an extraordinary skill. This award recognizes students studying at the interface of physics or mathematics with biology.
Harsh V. Patel, a biology major and computer science minor, is the 2018 recipient of the award. A School of Biological Sciences student ambassador with a keen analytical mind, Patel conducted research with Patrick McGrath and Greg Gibson, in the School of Biological Sciences.
When he first started research, Patel hoped to revolutionize genotype-phenotype mapping using machine learning. His computer science background allowed him to apply machine learning and probabilistic models to biology studies.
Virginia C. and Herschel V. Clanton Jr. Scholarship
Deep curiosity about the foundations of life also drives Nancy Park, the 2018 recipient. The scholarship goes to a top pre-health junior in the College of Sciences. Park is majoring in biology with a minor in physiology and a pre-health designation.
Park is a Fast-Track to Research Scholar and the president of Student Hospital Connections. She conducts research with Terry Snell, in the School of Biological Sciences.
“She really enjoys experimentation and discovery, and is constantly thinking of ways to improve techniques,” Snell says of Park. In Snell’s lab, Park has studied the sequencing of DNA from various rotifers and the metal toxicity to Proales similis.
Cynthia L. Bossart and James Efron Scholarship
This award recognizes the top out-of-state junior in the College of Sciences. The 2018 recipient is Katherine Wei. The biology major and health and medical sciences minor hopes to be a dentist.
In Todd Streelman’s lab, Wei studies the cichlid fish genome to explore the divergence of behavioral genes. Wei has had an integral role in advancing the understanding the genetic mechanisms of sex determination, a mentor says.
According to another mentor, Wei “only seems to express excitement as she dives into- and solves- new challenges and always has a positive impact on her projects and those around her.”
Wei serves as vice president of membership of the Pre-Dental Society and Stamps Health Services ambassador.
Robert A. Pierotti Memorial Scholarship
When it comes to solving challenges, Libby Taylor excels. She’s the 2018 recipient of the scholarship, which recognizes a top graduating senior in the College of Sciences. Taylor has already won the Alice T. Schafer Mathematics Prize, a prestigious nationwide award.
One of Taylor’s first challenges was taking Georgia Tech classes while still in high school. As an undergraduate, she went on to take several graduate level classes.
Taylor conducted research in combinatorics, tropical geometry, matroid theory, and random graph theory. According to her professors, when she came upon a foreign concept, she learned it on her own. One professor is “amazed at her ability to quickly pick up sophisticated ideas.” Another looks “forward to seeing what Taylor’s future holds.”
]]>Founding Members of the Organization include:
This article was edited from a story originally posted 5/24/2018 by Ben Brumfield.
]]>Georgia Institute of Technology
177 North Avenue
Atlanta, Georgia 30332-0181 USA
The College of Engineering ranked No. 8 (No. 4 among public universities), and all 11 of the programs within the college are ranked in the top 10, including:
Programs on the move include the College of Computing, which moved up from No. 9 to No. 8. Its programs are evaluated every four years by U.S. News and World Report, and it is the second time in the last three ranking periods in which the College of Computing improved its position.
The College of Computing also achieved rankings in the following specialties: Artificial Intelligence (No. 7), Programming Language (No. 16), Systems (No. 10) and Theory (No. 9).
In the College of Sciences, Chemistry jumped four to No. 20, Mathematics moved up two to No. 26, Physics moved up one to No. 28, Earth Sciences moved up four to No. 38, and Biology moved up one to No. 54. Within mathematics, the discrete math/combinatorics specialty had Georgia Tech at No. 2, up two positions.
The Scheller College of Business full-time MBA program moved up one to No. 28, and its part-time MBA moved up five to No. 25. Scheller was also ranked in the following specialties: Production/Operations (No. 7), Supply Chain/Logistics (No. 17) and Information Systems (No. 12).
In the Ivan Allen College of Liberal Arts, the Public Policy program moved up two to No. 43 overall with the Information and Technology Management specialty remaining at No. 2, Public Policy Analysis moved up two positions to No. 20 and the Environmental Policy and Management specialty debuting at No. 12.
This story was modified from a story originally published by Lance Wallace for the Georgia Tech News Center, March 20, 2018.
]]>Every semester, each of these Institutes picks an important topic, and invites the top experts in these fields to come interact, give lectures, workshops, and to train postdocs. These semesters are very influential and set the direction of research nationally and internationally.
In recent years, our collegues in the SoM have been selected as organizers of several of these institutes, confirming the global leadership of the School of Mathematics here at Georgia Tech in several important areas of Mathematics.
Last year, Prof. P. Tetali and adjunct Prof. D. Randall were Co-PI's of a successful grant to organize an "Transdisciplinary Research Institute for Advancing Data Science" for the NSF. https://www.nsf.gov/awardsearch/showAward?AWD_ID=1740776
In Fall '18, Prof. A. Fathi will be the lead organizer and Prof. R. de la Llave will be an organizer of a "jumbo" program on "Hamiltonian systems, from topology to applications through analysis" at MSRI. https://www.msri.org/programs/305
In Fall '18, Prof. A. Leykin will be the organizer of a program in "Nonlinear Algebra" for ICERM. https://icerm.brown.edu/programs/sp-f18/
In Spring '17, Prof. M. Lacey was one of the lead organizers of a program in "Harmonic Analysis" at MSRI. https://www.msri.org/programs/300
In Fall '14, and again in Spring '15, Prof. P. Tetali was one of organizers of the program on "Discrete Structures: Analysis and Applications" at IMA. https://www.ima.umn.edu/2014-2015
]]>