{"526001":{"#nid":"526001","#data":{"type":"event","title":"BioE PhD Defense Announcement- Yunfeng Chen","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Cheng Zhu (BioE, Gatech)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Larry McIntire (BioE, Gatech)\u003Cbr \/\u003E Dr. Wilbur Lam (BioE, Gatech)\u003Cbr \/\u003E Dr. Xiaoping Du (University of Illinois at Chicago)\u003Cbr \/\u003E Dr. Renhao Li (Emory University)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201c\u003Cstrong\u003EPlatelet Mechanosensing via Surface Receptors GPIb\u03b1 and Integrin \u003C\/strong\u003E\u003Cstrong\u003E\u03b1\u003C\/strong\u003E\u003Cstrong\u003E\u003Csub\u003EIIb\u003C\/sub\u003E\u003C\/strong\u003E\u003Cstrong\u003E\u03b2\u003C\/strong\u003E\u003Cstrong\u003E\u003Csub\u003E3\u003C\/sub\u003E\u003C\/strong\u003E\u201d\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EIn hemostasis and thrombosis, platelet adhesion and signaling play key roles. Two platelet receptors, glycoprotein Ib\u03b1 (GPIb\u03b1) and integrin \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E, mediate the early and mid-stages of platelet adhesion in arterial environments. GPIb\u03b1 is part of the GPIb\u03b1-V-IX complex that constitutes the receptor for von Willebrand factor (VWF). Its binding to VWF A1 domain enables rolling of platelets on the sites of vascular injury. \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E, upon activation, allows for platelet stable adhesion to the sub-endothelial surface and facilitates the platelets aggregation by cross-linking via soluble fibrinogen, fibronectin and VWF. GPIb\u03b1 and \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E has been reported to trigger outside-in mechano-activating signals upon ligand engagement in a sequential fashion, but exactly how the extracellular mechano-signals are transduced and translated to intracellular chemical signals remains unknown. In my PhD thesis research, I study GPIb\u03b1 and \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E in the context of platelet adhesion and signal initiation. I conduct single-molecule and single-cell level experiments to investigate 1) the conformational and functional dynamics of integrin molecules under mechanical forces; and 2) the relation between mechanical signals received by GPIb\u03b1 and \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E and platelet activation readouts, including intraplatelet Ca\u003Csup\u003E2+\u003C\/sup\u003E signals, \u03b2\u003Csub\u003E3\u003C\/sub\u003E integrins up-regulation, P-selectin expression and more, and decode the signaling transduction process step-by-step.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201c\u003Cstrong\u003EPlatelet Mechanosensing via Surface Receptors GPIb\u03b1 and Integrin \u003C\/strong\u003E\u003Cstrong\u003E\u03b1\u003C\/strong\u003E\u003Cstrong\u003E\u003Csub\u003EIIb\u003C\/sub\u003E\u003C\/strong\u003E\u003Cstrong\u003E\u03b2\u003C\/strong\u003E\u003Cstrong\u003E\u003Csub\u003E3\u003C\/sub\u003E\u003C\/strong\u003E\u201d- Yunfeng Chen\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cPlatelet Mechanosensing via Surface Receptors GPIb\u03b1 and Integrin \u03b1IIb\u03b23\u201d"}],"uid":"27917","created_gmt":"2016-04-18 08:05:55","changed_gmt":"2017-04-13 21:15:59","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-23T11:00:00-04:00","event_time_end":"2016-05-23T13:00:00-04:00","event_time_end_last":"2016-05-23T13:00:00-04:00","gmt_time_start":"2016-05-23 15:00:00","gmt_time_end":"2016-05-23 17:00:00","gmt_time_end_last":"2016-05-23 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}