{"56243":{"#nid":"56243","#data":{"type":"event","title":"ChBE Fall Seminar Series  Samir Mitragotri","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ESamir Mitragotri\u003C\/strong\u003E of the University of California, Santa Barbara presents \u003Cem\u003EEngineering Shape of Polymeric Micro and Nanoparticles for Drug Delivery\u003C\/em\u003E\n\u003C\/p\u003E\n\u003Cp\u003ERefreshments will be served from 3:30-4:00PM\u003Cbr \/\u003E\nThe seminar will be held 4:00-5:00PM\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003ESeminar Abstract:\u003C\/strong\u003E\u003Cbr \/\u003E\nPolymeric micro- and nanoparticles are routinely used for applications in drug delivery. Encapsulation of drugs in polymeric carriers protects them from enzymatic degradation and provides sustained release over prolonged periods. Further, encapsulation also allows drug targeting via cell and tissue-specific ligands. The performance characteristics of polymeric particles in the body, for example circulation times, macrophage clearance, targeting and drug release rates, depend on several particle parameters including size, shape, surface chemistry, and mechanical strength. Our research aims at developing quantitative laws describing the relationships between particle design and performance. We particularly focus on engineering particle shape, a design parameter that has received little attention in the past. We have devised methods to generate particles of several distinct shapes and studied their impact on key processes in drug delivery, in particular phagocytosis, the clearance of particles by macrophages. Our results show that particle shape makes a profound impact on phagocytosis, more so that particle size. Based on this understanding, we have designed novel polymeric particles possessing complex shapes that are highly resistant to phagocytosis. These studies reveal that particle shape provides a new dimension in engineering of polymeric carriers and opens up new opportunities in drug delivery.\n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cstrong\u003ESamir Mitragotri\u003C\/strong\u003E of the University of California, Santa Barbara presents \u003Cem\u003EEngineering Shape of Polymeric Micro and Nanoparticles for Drug Delivery\u003C\/em\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Samir Mitragotri of UCSB presents lecture"}],"uid":"27255","created_gmt":"2010-05-20 11:47:32","changed_gmt":"2016-10-08 01:51:41","author":"Josie Giles","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2006-09-13T16:30:00-04:00","event_time_end":"2006-09-13T18:00:00-04:00","event_time_end_last":"2006-09-13T18:00:00-04:00","gmt_time_start":"2006-09-13 20:30:00","gmt_time_end":"2006-09-13 22:00:00","gmt_time_end_last":"2006-09-13 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1240","name":"School of Chemical and Biomolecular Engineering"}],"categories":[],"keywords":[{"id":"6640","name":"ChBE Seminar Series"},{"id":"6641","name":"Georgia Tech seminars"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EJosie Giles\u003C\/strong\u003E\u003Cbr \/\u003ESchool of Chemical \u0026amp; Biomolecular Engineering\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=jg234\u0022\u003EContact Josie Giles\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-2299\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}