{"585418":{"#nid":"585418","#data":{"type":"event","title":"PhD Proposal by Zhou Yuan","body":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation- Zhou Yuan\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EZhou Yuan\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPh. D Proposal Presentation\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWednesday, January 18\u003Csup\u003Eth\u003C\/sup\u003E, 2017, 3pm\u003C\/p\u003E\r\n\r\n\u003Cp\u003E3:00pm, IBB Seminar Room 1128\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Zhu (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Susan Thomas (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr.\u0026nbsp;Michelle Krogsgaard (New York University)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr.\u0026nbsp;Mandy Ford (Emory University)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Gabe Kwong (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EUnderstanding the effect of tumor microenvironment on T cell antigen recognition\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESkin cancer is the most common cancer in the United States, among which melanoma is the most serious type with high mortality rate. Despite the critical role of CD8\u003Csup\u003E+\u003C\/sup\u003E T cells in tumor clearance, their functions in the tumor microenvironment (TME) are impaired by immunosuppressive cells\/cytokines, inhibitory receptors, and metabolic restriction. Targeting these pathways were shown to promote tumor clearance, yet unknown mechanisms may still exist curtailing the T cell responses. T cell activation has been shown to be largely determined by the \u003Cem\u003Ein situ\u003C\/em\u003E mechanokinetic properties of the binding of T cell receptor (TCR) to peptide-major histocompatibility complex (pMHC), which are sensitive to perturbations of the cellular environment. Our preliminary studies have shown that the molecular interactions involved in T cell antigen recognition are altered in the TME.\u003Cstrong\u003E The present thesis will study the extent of this alteration, how such alteration consequentially suppresses T cell effector functions, and what the underlying mechanisms are\u003C\/strong\u003E. This study aims to address these questions with animal models, highly-sensitive biomechanical assays of single molecules, and other cellular and bimolecular approaches. The outcome will greatly enhance our understanding of the impaired anti-tumor T cell responses and inspire novel strategies for cancer immunotherapy.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Understanding the effect of tumor microenvironment on T cell antigen recognition "}],"uid":"27707","created_gmt":"2017-01-03 14:26:03","changed_gmt":"2017-01-03 14:26:03","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-01-18T15:00:00-05:00","event_time_end":"2017-01-18T17:00:00-05:00","event_time_end_last":"2017-01-18T17:00:00-05:00","gmt_time_start":"2017-01-18 20:00:00","gmt_time_end":"2017-01-18 22:00:00","gmt_time_end_last":"2017-01-18 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}