{"587239":{"#nid":"587239","#data":{"type":"event","title":"BME Speaker Seminar with Lukasz Bugaj, Ph.D.*","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E*** FACULTY CANDIDATE ***\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Ch3\u003ELukasz Bugaj, Ph.D.*\u003C\/h3\u003E\r\n\r\n\u003Cp\u003EArnold O. Beckman Postdoctoral Fellow,\u0026nbsp;\u003Cbr \/\u003E\r\nUniversity of California, San Francisco\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Ch3\u003EInterrogating Cell Signal Perception Using Optogenetics\u003C\/h3\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT\u003C\/strong\u003E\u003Cbr \/\u003E\r\nDespite decades of cell signaling studies, we have a limited understanding of the cell signaling code: how can cells make diverse and complex decisions using only a small set of intracellular signaling pathways? An intriguing hypothesis is that cells can decode the strength, dynamics, or combinations of intracellular signals. Optogenetic \u0026ndash; or light activatible \u0026ndash; tools now enable us to test this hypothesis through precise and tunable control over signaling inputs in living cells.\u0026nbsp; These tools allow us to reverse-engineer the cell, giving fundamental insight into both 1) the cellular machinery and 2) the cell\u0026rsquo;s ability to process and interpret its dynamic environment. In this talk, I will first describe the engineering of optogenetic proteins for cell signaling, as well as their high-throughput implementation. I will then show how these approaches are revealing principles by which signaling dynamics govern cell fate decisions from neurogenesis to cancer cell proliferation.\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nHost: \u003Ca href=\u0022mailto:edward.botchwey@bme.gatech.edu\u0022 target=\u0022_blank\u0022\u003EEdward Botchwey, Ph.D.\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003EThursday, February 16\u003C\/strong\u003E\u003Cbr \/\u003E\r\n10:30 a.m.\u003Cbr \/\u003E\r\nMcIntire Room 3115,\u003Cbr \/\u003E\r\nWhitaker Bldg.\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nVideoconference:\u003Cbr \/\u003E\r\nEmory: HSRB E182\u003Cbr \/\u003E\r\nGeorgia Tech:\u0026nbsp;TEP 104\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"BME Speaker Seminar with Lukasz Bugaj, Ph.D.*"}],"uid":"27513","created_gmt":"2017-02-09 15:47:18","changed_gmt":"2017-04-13 21:12:55","author":"Walter Rich","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-02-16T10:30:00-05:00","event_time_end":"2017-02-16T11:30:00-05:00","event_time_end_last":"2017-02-16T11:30:00-05:00","gmt_time_start":"2017-02-16 15:30:00","gmt_time_end":"2017-02-16 16:30:00","gmt_time_end_last":"2017-02-16 16:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"587238":{"id":"587238","type":"image","title":"Lukasz Bugaj, Ph.D.*","body":null,"created":"1486654883","gmt_created":"2017-02-09 15:41:23","changed":"1486654883","gmt_changed":"2017-02-09 15:41:23","alt":"Lukasz Bugaj, Ph.D.*","file":{"fid":"223806","name":"Lukasz Bugaj photo-315pxHigh.jpg","image_path":"\/sites\/default\/files\/images\/Lukasz%20Bugaj%20photo-315pxHigh.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Lukasz%20Bugaj%20photo-315pxHigh.jpg","mime":"image\/jpeg","size":76915,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Lukasz%20Bugaj%20photo-315pxHigh.jpg?itok=WgrNJm1F"}}},"media_ids":["587238"],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"1612","name":"BME"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:edward.botchwey@bme.gatech.edu\u0022\u003EEdward Botchwey\u003C\/a\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}