{"587361":{"#nid":"587361","#data":{"type":"event","title":"BME Speaker Seminar with Leo Chou, Ph.D.*","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E*** FACULTY CANDIDATE ***\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Ch3\u003ELeo Chou, Ph.D.*\u003C\/h3\u003E\r\n\r\n\u003Cp\u003ENSERC Banting Postdoctoral Fellow\u003Cbr \/\u003E\r\nWyss Institute at Harvard University\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Ch3\u003EDesigning Biosynthetic Nanosystems with\u003Cbr \/\u003E\r\nNon-equilibrium Behaviours\u003C\/h3\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT\u003C\/strong\u003E\u003Cbr \/\u003E\r\nBiomolecules in living systems operate as dynamic complexes to transmit energy, force, and motion within and between cells. These molecular machines reflect the sophisticated functions that can emerge from the hierarchical organization of simple building blocks, and highlight the importance of both structure and dynamics in designing materials for in vivo applications.\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nIn this talk I will discuss how DNA-directed assembly is enabling the design of nanoscale systems with tunable dynamic behaviours and highlight their biological applications. In the first example, DNA is used to organize functional nanoparticle building blocks into superstructures with prescribed physicochemical properties. By controlling design parameters such as nanoparticle shape, surface chemistry, and assembly architecture, DNA-nanoparticle superstructures can exhibit rich, emergent properties such as (1) kinetically programmable, multistage cargo release, and (2) switchable cell internalization. In the second part of the talk, I will describe on-going efforts to construct a virus-inspired, RNA-extruding nanofactory. The nanofactory spatially coordinates the activities of a RNA polymerase, its DNA template, and associated ribonucleases within a 150 x 60 nm \u0026ldquo;DNA origami\u0026rdquo; nanocapsule. By spatially confining these enzymes, the nanofactory is capable of producing RNA more efficiently and with more engineering control than its molecular counterparts, and may one day find applications as artificial organelles for on-site therapeutic manufacturing directly within living cells.\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nHost:\u0026nbsp;\u003Ca href=\u0022mailto:snie@emory.edu\u0022 target=\u0022_blank\u0022\u003EShuming Nie, Ph.D.\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003ETuesday, Feb. 21\u003C\/strong\u003E\u003Cbr \/\u003E\r\n10:30 a.m.\u003Cbr \/\u003E\r\nHSRB Room E160,\u0026nbsp;\u0026nbsp;\u003Cbr \/\u003E\r\nEmory University\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nVideoconference:\u003Cbr \/\u003E\r\nGeorgia Tech, McIntire Rm 3115 and\u0026nbsp;TEP 104\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"BME Speaker Seminar with Leo Chou, Ph.D.*"}],"uid":"27513","created_gmt":"2017-02-13 20:17:05","changed_gmt":"2017-04-13 21:12:52","author":"Walter Rich","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-02-21T10:30:00-05:00","event_time_end":"2017-02-21T11:30:00-05:00","event_time_end_last":"2017-02-21T11:30:00-05:00","gmt_time_start":"2017-02-21 15:30:00","gmt_time_end":"2017-02-21 16:30:00","gmt_time_end_last":"2017-02-21 16:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"587360":{"id":"587360","type":"image","title":"Leo Chou, Ph.D.*","body":null,"created":"1487016752","gmt_created":"2017-02-13 20:12:32","changed":"1487016752","gmt_changed":"2017-02-13 20:12:32","alt":"Leo Chou, Ph.D.*","file":{"fid":"223849","name":"Leo Chou headshot 315px.jpg","image_path":"\/sites\/default\/files\/images\/Leo%20Chou%20headshot%20315px.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Leo%20Chou%20headshot%20315px.jpg","mime":"image\/jpeg","size":97852,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Leo%20Chou%20headshot%20315px.jpg?itok=3POTdfR_"}}},"media_ids":["587360"],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"1612","name":"BME"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:snie@emory.edu\u0022 target=\u0022_blank\u0022\u003EShuming Nie, Ph.D.\u003C\/a\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}