{"589102":{"#nid":"589102","#data":{"type":"event","title":"Cell Manufacturing Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0026quot;Towards Personalized Healthcare Engineering: A New Paradigm in Blood Disorder Treatment\u0026quot;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAthanasios (Sakis) Mantalaris, Ph.D.\u0026nbsp;\u003Cbr \/\u003E\r\nProfessor\u003Cbr \/\u003E\r\nBiological Systems Engineering Laboratory\u003Cbr \/\u003E\r\nDepartment of Chemical Engineering\u003Cbr \/\u003E\r\nImperial College of London\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPersonalized medicine is a medical model that proposes the customization of healthcare, with decisions and practices being tailored to the individual patient by use of patient-specific information (initially genetics information) and\/or the application of patient-specific cell-based therapies. The BioBlood project aims to deliver personalized healthcare through a \u0026ldquo;step change\u0026rdquo; in the clinical field of haemato-oncology. BioBlood represents an engineered bio-inspired integrated experimental\/modeling platform for normal and abnormal haematopoiesis that receives disease \u0026amp; patient input (patient primary cells \u0026amp; patient\/disease-specific data) and will produce cellular (red blood cell product) and drug (optimal drug treatment) therapies as its output. An experimental platform will be presented, which is a novel three-dimensional hollow fibre bioreactor capable of culturing normal and abnormal haematopoietic cells in the absence of exogenous growth factors by mimicking the structure and function of the bone marrow. Characterization of the experimental platform at the cellular and molecular level will be presented. In addition, the in silico platform that captures cellular heterogeneity using a population balance model (PBM) in leukaemia will also be presented. The PBM, which is able to extract patient- and disease-specific information is linked to a pharmacokinetic\/pharmacodynamic (PD\/PD) model, which is then used to optimize chemotherapy treatment in a personalized manner.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EThis presentation can be seen via videoconference using\u0026nbsp;BlueJeans: \u003Ca href=\u0022https:\/\/bluejeans.com\/179735194\u0022 target=\u0022_blank\u0022\u003Ehttps:\/\/bluejeans.com\/179735194\u003C\/a\u003E\u003C\/em\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u0022Towards Personalized Healthcare Engineering: A New Paradigm in Blood Disorder Treatment\u0022 - Athanasios (Sakis) Mantalaris, Ph.D. - Imperial College of London"}],"uid":"27349","created_gmt":"2017-03-22 14:50:57","changed_gmt":"2017-04-17 14:09:28","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-05-01T11:00:00-04:00","event_time_end":"2017-05-01T12:00:00-04:00","event_time_end_last":"2017-05-01T12:00:00-04:00","gmt_time_start":"2017-05-01 15:00:00","gmt_time_end":"2017-05-01 16:00:00","gmt_time_end_last":"2017-05-01 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/cellmanufacturing.gatech.edu\/","title":"Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M)"},{"url":"https:\/\/www.imperial.ac.uk\/people\/a.mantalaris","title":"Mantalaris profile"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:krish.roy@gatech.edu\u0022\u003EKrish Roy\u003C\/a\u003E - faculty host\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}