{"597780":{"#nid":"597780","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Bailey Hannon","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EC. Ross Ethier\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, PhD, Co-Chair (\u003C\/em\u003E\u003Cem\u003EWallace H. Coulter Department of \u003C\/em\u003E\u003Cem\u003EBiomedical Engineering, Georgia Institute of Technology and Emory University)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EMachelle Pardue\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, PhD, Co-Chair (\u003C\/em\u003E\u003Cem\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/em\u003E\u003Cem\u003E, Georgia Institute of Technology and Emory University)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EBrandon Dixon\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, PhD (George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EMark Prausnitz\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, PhD (Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EBrian Samuels\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, MD, PhD (Department of Ophthalmology, University of Alabama, Birmingham)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EStiffening the Posterior Rat Sclera to Provide Neuroprotection in Glaucoma\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGlaucoma is the leading cause of irreversible blindness in the world, expected to affect approximately 80 million people by the year 2020. This degenerative optic neuropathy is characterized by retinal ganglion cell (RGC) death, optic nerve damage, and progressive vision loss. While the exact etiology remains elusive, elevated intraocular pressure (IOP) is a known risk factor and lowering IOP remains the only effective treatment. Elevated IOP causes deformation and remodeling of the optic nerve head (ONH) tissues, which in turn is thought to lead to localized neurodegeneration. Computational and \u003Cem\u003Eex vivo\u003C\/em\u003E studies have shown that scleral stiffness strongly influences deformation of the ONH, and that increasing the stiffness of the portion of the sclera surrounding the ONH (the peripapillary sclera) can significantly reduce these excessive strains. We \u003Cstrong\u003Ehypothesize\u003C\/strong\u003E that by crosslinking the collagenous peripapillary sclera, we will reduce mechanical deformation in the ONH, which will in turn provide neuroprotection to mitigate glaucomatous vision loss. To investigate this hypothesis, we will develop and evaluate the efficacy of a nontoxic scleral stiffening treatment in a commonly-used rat model of glaucoma, which will lay the foundation for future glaucoma therapies.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0026quot;Stiffening the Posterior Rat Sclera to Provide Neuroprotection in Glaucoma\u0026quot;- Bailey Hannon\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Stiffening the Posterior Rat Sclera to Provide Neuroprotection in Glaucoma\u0022"}],"uid":"27917","created_gmt":"2017-10-24 12:55:05","changed_gmt":"2017-10-24 12:55:05","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-11-06T13:00:00-05:00","event_time_end":"2017-11-06T15:00:00-05:00","event_time_end_last":"2017-11-06T15:00:00-05:00","gmt_time_start":"2017-11-06 18:00:00","gmt_time_end":"2017-11-06 20:00:00","gmt_time_end_last":"2017-11-06 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}