{"599034":{"#nid":"599034","#data":{"type":"event","title":"MS defense by Tobias Hoffmann","body":[{"value":"\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMaster of Science\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETobias Hoffmann\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWill defend his thesis\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026ldquo;Regulation of the Type VI Secretion System in Environmental Isolates of \u003Cem\u003EVibrio cholerae\u003C\/em\u003E\u0026rdquo;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMonday, November 27\u003Csup\u003Eth\u003C\/sup\u003E, 2017\u003C\/p\u003E\r\n\r\n\u003Cp\u003E3:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKrone Engineered Biosystems Building(EBB), Children\u0026rsquo;s Healthcare of Atlanta Seminar Room (Room 1005)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Advisor\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Brian Hammer\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Thomas DiChristina (Biological Sciences)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Samuel Brown (Biological Sciences)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EVibrio cholerae\u003C\/em\u003E is\u003Cem\u003E \u003C\/em\u003Ea human pathogen that causes the severe diarrheal disease cholera, but can also inhabit aquatic environments. The type-VI secretion system (T6SS) is a macromolecular contractile machine that injects neighboring cells with cytotoxic effector proteins. Clinical strains of \u003Cem\u003EV. cholerae\u003C\/em\u003E express the T6SS only when exposed to high cell density and starvation conditions in the presence of chitin, a process regulated by the master regulator QstR. The atypical clinical isolate V52 expresses its T6SS constitutively, a trait shared by many \u003Cem\u003EV. cholerae \u003C\/em\u003Estrains isolated from the environment. Recently it was discovered that the TfoY regulator controls T6SS expression independent of \u003Cem\u003EqstR \u003C\/em\u003Ein V52. In examining strains from environmental sources, I found that one constitutive environmental strain is also under \u003Cem\u003EtfoY\u003C\/em\u003E control. However, I also uncovered that T6SS-mediated constitutive killing in four other environmental strains was unaffected by a \u003Cem\u003EtfoY\u003C\/em\u003E deletion. Furthermore, I demonstrated that other known regulators (TfoX, QstR, OscR) also played no role in T6SS expression in these strains. For example, the environmental strain BGT69 remains capable of T6SS-mediated killing when these four known T6SS regulators were deleted. These results suggest the presence of a novel regulatory pathway(s) for type-VI secretion in this and other environmental isolates of \u003Cem\u003EV. cholerae\u003C\/em\u003E.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Regulation of the Type VI Secretion System in Environmental Isolates of Vibrio cholerae"}],"uid":"27707","created_gmt":"2017-11-21 18:09:17","changed_gmt":"2017-11-21 18:11:29","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-11-27T15:00:00-05:00","event_time_end":"2017-11-27T17:00:00-05:00","event_time_end_last":"2017-11-27T17:00:00-05:00","gmt_time_start":"2017-11-27 20:00:00","gmt_time_end":"2017-11-27 22:00:00","gmt_time_end_last":"2017-11-27 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"111531","name":"ms defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}