{"604000":{"#nid":"604000","#data":{"type":"event","title":"Network Mechanisms Underlying Stable Motor Actions","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EWilliam Liberti, Ph.D.\u003Cbr \/\u003E\r\nDepartment of Electrical Engineering \u0026amp; Computer Science\u003Cbr \/\u003E\r\nUniversity of California, Berkeley\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003Cbr \/\u003E\r\nPrecise motor skills are acquired and maintained through practice; a process of exploratory trial-and-error learning where evaluation mechanisms can differentially reinforce network patterns that produce more desired outcomes and weaken or punish patterns of activity that produce worse outcomes. However, the neural underpinnings of how practice may evaluate, maintain and sharpen the stereotypy of a precise motor action are not well understood. The zebra finch songbird offers a chance to explore the mechanisms of motor maintenance in a \u0026nbsp;particularly well defined setting: song is a constrained behavior that naturally converges around a set point, and is actively maintained and stabilized in light of external feedback and environmental challenges. While song is primarily a courtship ritual to attract females, finches will also sing in isolation, otherwise known as \u0026lsquo;undirected\u0026rsquo; song, \u0026nbsp;and these songs have comparatively lower stereotypy.\u0026nbsp; Undirected song could serve as an opportunity for premotor networks to explore potentially better configurations to optimize motor output, since the performance outcome is less critical. We developed custom carbon fiber microelectrodes, cell-type specific genetic tools, and ultra-light head-mounted miniscopes to investigate the mechanistic basis of long-term motor stability of the premotor area HVC. We find that during undirected practice, some neurons are active more probabilistically, and less robustly, and trial to trial variability is not highly correlated across cells. In contrast, when song is directed to a female, this exploration is largely diminished.\u0026nbsp; In addition, while the timing of projection neurons is extremely stereotyped and precise within a day, neurons can \u0026lsquo;dropout\u0026rsquo; and new neurons can \u0026lsquo;drop-in\u0026rsquo; \u0026nbsp;across days- \u0026nbsp;largely over intervals of sleep. In spite of these shifts at the single neuron level, local ensembles and inhibitory interneurons produce reliable patterns of activity over month-long timescales. These observations suggest that state-dependent variations could contribute to the long-term stability of the motor network, and that stereotyped motor skills can be supported by stable ensemble dynamics that persist in spite of single neuron instability.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EPhysiology Brownbag Seminars\u003C\/strong\u003E\u003Cbr \/\u003E\r\nThe Physiology Group in the School of Biological Sciences hosts Brownbag Lunchtime Seminars twice a month on Wednesdays at noon in room 1253 of the Applied Physiology Building located at 555 14th Street NW, Atlanta, GA 30318. You are welcome to bring a lunch and join us as we ruminate with us on topics in Physiology! A full listing of seminars can be found at \u003Ca href=\u0022http:\/\/pwp.gatech.edu\/bmmc\/seminars\/\u0022\u003Ehttp:\/\/pwp.gatech.edu\/bmmc\/seminars\/\u003C\/a\u003E.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A Physiology Brownbag Seminar"}],"uid":"27964","created_gmt":"2018-03-19 19:31:17","changed_gmt":"2018-03-19 19:31:17","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-04-04T13:00:00-04:00","event_time_end":"2018-04-04T14:00:00-04:00","event_time_end_last":"2018-04-04T14:00:00-04:00","gmt_time_start":"2018-04-04 17:00:00","gmt_time_end":"2018-04-04 18:00:00","gmt_time_end_last":"2018-04-04 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"603998":{"id":"603998","type":"image","title":"William Liberti","body":null,"created":"1521486007","gmt_created":"2018-03-19 19:00:07","changed":"1521486007","gmt_changed":"2018-03-19 19:00:07","alt":"","file":{"fid":"230214","name":"William-Liberti.jpg","image_path":"\/sites\/default\/files\/images\/William-Liberti.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/William-Liberti.jpg","mime":"image\/jpeg","size":4693,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/William-Liberti.jpg?itok=dmJEk-WG"}}},"media_ids":["603998"],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"173857","name":"T. Richard Nichols"},{"id":"166882","name":"School of Biological Sciences"},{"id":"177490","name":"William Liberti"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EHost: \u003Ca href=\u0022mailto:trn@gatech.edu\u0022\u003ET. Richard Nichols, Ph.D.\u003C\/a\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}