{"60544":{"#nid":"60544","#data":{"type":"news","title":"Eva Lee Joins Interdisciplinary Team at Emory\u2019s New Center for Systems Vaccinology","body":[{"value":"\u003Cp\u003EEva K. Lee, professor\nin the H. Milton Stewart School of Industrial and Systems Engineering at\nGeorgia Tech and director of the \u003Ca href=\u0022http:\/\/www.isye.gatech.edu\/%7Eevakylee\/medicalor\u0022\u003ECenter for\nOperations Research in Medicine and HealthCare\u003C\/a\u003E,\njoins a highly integrated and interdisciplinary team conducting research in the\nnewly established Center for Systems Vaccinology at \u003Ca href=\u0022http:\/\/www.emory.edu\/home\/index.html\u0022\u003EEmory University\u003C\/a\u003E. \u003C\/p\u003E\n\n\n\n\u003Cp\u003EThe \u003Ca href=\u0022http:\/\/www.niaid.nih.gov\/Pages\/default.aspx\u0022\u003ENational Institute of Allergy and\nInfectious Diseases \u003C\/a\u003Eof the \u003Ca href=\u0022http:\/\/www.nih.gov\/\u0022\u003ENational Institutes of Health\u003C\/a\u003E awarded a five-year,\n$15.5 million grant to the \u003Ca href=\u0022\/\/www.yerkes.emory.edu\/emory-vaccine-center-0\u0022\u003EEmory Vaccine Center \u003C\/a\u003Eat \u003Ca href=\u0022http:\/\/www.yerkes.emory.edu\/\u0022\u003EYerkes National Primate\nResearch Center\u003C\/a\u003E in Atlanta. Scientists in the new Center will employ the modern analytic\ntools of systems biology to understand the immune responses vaccines stimulate\nin humans and will use this knowledge to guide design of vaccines against HIV,\nmalaria and other global pandemics\u003C\/p\u003E\n\n\n\n\u003Cp\u003EBali Pulendran, the\nCharles Howard Candler professor in the Department of Pathology and Laboratory\nMedicine at Emory University, the Emory Vaccine\nCenter, and Yerkes Research Center, is principal investigator of the center.\nRafi Ahmed, director of the Emory Vaccine Center and a Georgia Research\nAlliance Eminent Scholar, will serve as co-principal investigator.\u003C\/p\u003E\n\n\n\n\u003Cp\u003ELee and other\nresearchers at the center will address a major challenge thus far in the\ndevelopment of vaccines \u2013 that the effectiveness of vaccination can only be\nascertained after vaccinated individuals have been exposed to infection. To\nstudy vaccine-induced immunity in humans, they will use a multidisciplinary\napproach Pulendran developed, which involves immunology, genomics and\nbioinformatics to predict the immunity of a vaccine without exposing\nindividuals to infection. \u003C\/p\u003E\n\n\n\n\n\n\u003Cp\u003EResearchers working in the new Center for\nSystems Vaccinology will determine whether Pulendran\u2019s approach can be used to\npredict the effectiveness of other vaccines, including common vaccines against\ninfluenza, pneumococcal disease and shingles. The ability to successfully\npredict the immunity and efficacy of vaccines would facilitate the rapid\nevaluation of new and emerging vaccines and the identification of individuals\nwho are unlikely to be protected by a vaccine.\u003C\/p\u003E\u003Cp\u003EThe team\u2019s initial work will focus on two\nmajor projects on innate immunity and adaptive immunity that ultimately will\nfacilitate vaccine development in several ways: (1) by enabling a strategy to\nprospectively predict the immunogenicity of vaccines; (2) by offering new and\nfundamental insights into the genes, cells and networks that orchestrate\nvaccine-induced immunity in the young and elderly; and (3) by facilitating the\ngeneration of an open access database of vaccine-induced molecular signatures.\u003C\/p\u003E\n\n\u003Cp\u003EThe Center\u2019s\ninterdisciplinary team comprises researchers and clinicians in areas as diverse\nas immunology, vaccinology, clinical medicine, computational modeling, and\nmathematics. In addition to Lee, the team includes Nick Haining (Dana Farber\nCancer Institute, Boston), Shankar Subramaniam (University of California, San\nDiego), Alex Sette (La Jolla Institute for Allergy and Immunology, La Jolla),\nMark Mulligan (Hope Clinic, Emory Vaccine Center,; and Myron Levine and Adriana\nWeinberg (University of Colorado, Denver).\u003C\/p\u003E\n\n\n\n\u003Cp\u003ELee,\nalong with Haining and Subramaniam, co-direct the \u0022Genomics and\nComputational Biology\u0022 core of the initiative. The Core will provide\nexpertise, analysis, and experimental platforms to systematically interrogate\nthe immune response to the inactivated trivalent influenza vaccine, the\npneumococcal polysaccharide vaccine, and the live attenuated varicella-zoster\nvaccine. Two major goals in this Core involve development of gene\nexpression-based predictors of vaccine response in humans and use of genomic techniques\nas discovery tools to better understand the innate and adaptive immune response\nto vaccines.\u003C\/p\u003E\n\n\n\n\u003Cp\u003ESupport for the first\nyear of the Center initiative will come from the American Recovery and\nReinvestment Act (ARRA).\u003C\/p\u003E\n\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EEva K. Lee, professor\nin the H. Milton Stewart School of Industrial and Systems Engineering at\nGeorgia Tech and director of the \u003Ca href=\u0022http:\/\/www.isye.gatech.edu\/%7Eevakylee\/medicalor\u0022\u003ECenter for\nOperations Research in Medicine and HealthCare\u003C\/a\u003E,\njoins a highly integrated and interdisciplinary team conducting research in the\nnewly established Center for Systems Vaccinology at Emory University.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Eva Lee Joins Interdisciplinary Team at Emory\u2019s New Center for Systems Vaccinology"}],"uid":"27328","created_gmt":"2010-08-24 09:07:38","changed_gmt":"2016-10-08 03:07:15","author":"Edie Cohen","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2010-08-24T00:00:00-04:00","iso_date":"2010-08-24T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"55544":{"id":"55544","type":"image","title":"Eva K. Lee, ISyE professor and director, Center for Operations Research in Medicine and HealthCare","body":null,"created":"1449175533","gmt_created":"2015-12-03 20:45:33","changed":"1475894491","gmt_changed":"2016-10-08 02:41:31","alt":"Eva K. Lee, ISyE professor and director, Center for Operations Research in Medicine and HealthCare","file":{"fid":"190311","name":"Eva-Lee_th.jpg","image_path":"\/sites\/default\/files\/images\/Eva-Lee_th_1.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Eva-Lee_th_1.jpg","mime":"image\/jpeg","size":30557,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Eva-Lee_th_1.jpg?itok=JsYh6QcC"}}},"media_ids":["55544"],"groups":[{"id":"1242","name":"School of Industrial and Systems Engineering (ISYE)"}],"categories":[{"id":"134","name":"Student and Faculty"}],"keywords":[{"id":"1043","name":"eva lee"},{"id":"109","name":"Georgia Tech"},{"id":"426","name":"isye"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:barbara.christopher@isye.gatech.edu\u0022\u003E\u003Cstrong\u003EBarbara \nChristopher\u003C\/strong\u003E\u003C\/a\u003E\u003Cbr \/\u003EIndustrial and Systems Engineering\u003Cbr \/\u003E\u003Cstrong\u003E404.385.3102\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}