{"607571":{"#nid":"607571","#data":{"type":"event","title":"MS Defense by Kelly Hyland","body":[{"value":"\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EKelly Hyland\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBioE\u0026nbsp;MS Thesis Defense\u003C\/p\u003E\r\n\r\n\u003Cp\u003E1:00 pm, Friday,\u0026nbsp;July 20th 2018,\u0026nbsp;Engineered Biosystems Building Room 3029\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Julie Champion, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E:\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndres Garcia, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EValeria Milam, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EImmobilization of Adhesive Protein Domains in PEG Hydrogels\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca name=\u0022x__Hlk512943777\u0022\u003EThe fundamental goal of biomaterials design for regenerative medicine is to promote the restoration of functional tissue. In wound healing research, one strategy is to introduce\u0026nbsp;space-filling materials, or scaffolds, to intervene and prevent scarring. The scaffold\u0026nbsp;must be nontoxic,\u0026nbsp;permit high rates of oxygen and small molecule diffusion, and offer tissue-matching\u0026nbsp;stiffness. Critically, they must also\u0026nbsp;promote attachment of wound healing cells. A class of materials called synthetic hydrogels meet the first three criteria, but must be functionalized with bioactive ligands to promote cell attachment.\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESynthetic\u0026nbsp;hydrogels, most numerously\u0026nbsp;poly(ethylene glycol) (PEG) hydrogels, offer a modular\u0026nbsp;platform for biomaterials design because the bioactive\u0026nbsp;ligand identity and density, as well as hydrogel stiffness, can be precisely and independently controlled.\u0026nbsp;However, PEG hydrogels have seldom been used as a 3D platform for investigating differences in cell behavior when in contact with different extracellular matrix protein domains.\u0026nbsp;Using recombinant protein design, expression, and characterization, this study\u0026nbsp;compares cell behavior when cultured on PEG\u0026nbsp;hydrogels presenting structured protein domains and minimum sequence peptides. We observe differences in cell morphology, protease production and attachment force when cultured on hydrogels with different adhesive protein domains.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Immobilization of Adhesive Protein Domains in PEG Hydrogels"}],"uid":"27707","created_gmt":"2018-07-09 14:40:14","changed_gmt":"2018-07-09 14:40:14","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-07-20T14:00:00-04:00","event_time_end":"2018-07-20T16:00:00-04:00","event_time_end_last":"2018-07-20T16:00:00-04:00","gmt_time_start":"2018-07-20 18:00:00","gmt_time_end":"2018-07-20 20:00:00","gmt_time_end_last":"2018-07-20 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"111531","name":"ms defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}