{"620976":{"#nid":"620976","#data":{"type":"news","title":"Desai Secures $2.8 Million Grant to Develop Steerable Robotic Guidewire","body":[{"value":"\u003Cp\u003EJaydev Desai, a professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University (BME) and director of the Georgia Center for Medical Robotics (\u003Ca href=\u0022http:\/\/medicalrobotics.gatech.edu\/\u0022\u003EGCMR\u003C\/a\u003E), has spent his career developing robotic tools to address challenging clinical problems. And the National Institutes of Health (NIH) has taken notice.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThrough the years, \u003Ca href=\u0022https:\/\/robomed.gatech.edu\/\u0022\u003EDesai\u003C\/a\u003E has secured several NIH R01 grants to support his work in this area, but recently the Institutes not only stepped up to support Desai\u0026rsquo;s latest project (which can fill a critical gap in the treatment of deadly atherosclerosis), it also ranked the researcher\u0026rsquo;s grant application with its highest degree of confidence \u0026ndash; a one percentile score.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026ldquo;That is highly encouraging,\u0026rdquo; Desai says. \u0026ldquo;It clearly demonstrates how critical and challenging the clinical problem is and why innovative engineering solutions need to be developed to address it.\u0026rdquo;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe NIH\u0026rsquo;s National Heart, Lung, and Blood Institute (NHLBI) awarded a $2.8 million grant to support Desai\u0026rsquo;s lab and his collaborators for an innovative project that features the first use of intravascular steerable robotic guidewire capable of forward-looking ultrasound imaging and image-guided navigation through vasculature and occluded vessels.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDesai explains that the ability to steer, visualize, and navigate the guidewire is highly novel and will eventually result in improvement of clinical workflow and patient treatment outcomes. \u0026ldquo;Think of a plumber\u0026rsquo;s snake,\u0026rdquo; Desai says. \u0026ldquo;And this is all about steering the tip of the long snake with visualization of where to go with ultrasound imaging.\u0026rdquo;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDesai\u0026rsquo;s collaborators include \u003Ca href=\u0022https:\/\/lindsey.gatech.edu\/\u0022\u003EBrooks Lindsey\u003C\/a\u003E (Coulter Department), \u003Ca href=\u0022https:\/\/ultrasound.gatech.edu\/\u0022\u003EStanislav Emelianov\u003C\/a\u003E (Coulter Department and School of Electrical and Computer Engineering), and from Emory, Muralidhar Padala (cardiothoracic surgery), Khusrow Niazi (interventional cardiology) and Zachary Bercu (interventional radiology).\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPatients with atherosclerosis can develop a buildup of fatty deposits, or plaque, within their arteries. These can lead to total blockages in the arteries, a condition called chronic total occlusion (CTO), which are the riskiest and most challenging vascular lesions to treat with traditional stenting or endovascular devices. The structure of the lesion (including a fibrous, calcific plaque) presents a complex technical challenge \u0026ndash; the stiff formation can bend guidewire tips. Even successful procedures, Desai points out, \u0026ldquo;are time consuming, involve chance, and require prolonged patient and physician exposure to radiation.\u0026rdquo;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026ldquo;The clinical challenge is well recognized in the community,\u0026rdquo; he adds. \u0026ldquo;Since endovascular approaches are increasingly utilized over conventional approaches, there is an urgent need to develop new technologies to meet this critical need!\u0026rdquo;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESo Desai\u0026rsquo;s team plans to address three specific aims:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026bull;\u0026nbsp;Design and develop a robotically steerable, 0.014-inch diameter guidewire (0.355 mm) system to accommodate a .350 mm x .350 mm ultrasound transducer at its tip, and can be steered with image feedback from the transducer.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026bull; Design and build a forward-looking transducer for the robotically steerable guidewire and an algorithm to reconstruct an image of the encountered occlusion.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026bull; Iteratively optimize the ultrasound-steerable guidewire design using 3D printed, patient-specific models of CTOs, realistic human cadaver limbs with CTO, and a live animal model of CTOs.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe highly interdisciplinary project combines expertise in medical robotics, ultrasound imaging, pulsatile flow models and image-guided interventions in animal models, interventional cardiology, and interventional radiology. The designed system, Desai says, \u0026ldquo;will have significant societal impact through improved patient outcomes, reduced radiation exposure for the physician and the patient, reduced rate of procedural failures, and lower healthcare costs.\u0026rdquo;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":[{"value":"NIH ranks researcher\u2019s proposal with its best possible score"}],"field_summary":[{"value":"\u003Cp\u003ENIH ranks researcher\u0026rsquo;s proposal with its best possible score\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"NIH ranks researcher\u2019s proposal with its best possible score"}],"uid":"28153","created_gmt":"2019-04-27 00:01:01","changed_gmt":"2019-04-29 13:02:58","author":"Jerry Grillo","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2019-04-26T00:00:00-04:00","iso_date":"2019-04-26T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"609741":{"id":"609741","type":"image","title":"Steerable Guidewire: Jaydev Desai, PhD ","body":null,"created":"1534269608","gmt_created":"2018-08-14 18:00:08","changed":"1556323292","gmt_changed":"2019-04-27 00:01:32","alt":"Steerable Guidewire: Jaydev Desai, PhD ","file":{"fid":"232208","name":"Jaydev-Desai.jpg","image_path":"\/sites\/default\/files\/images\/Jaydev-Desai_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Jaydev-Desai_0.jpg","mime":"image\/jpeg","size":1441404,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Jaydev-Desai_0.jpg?itok=241_gwJs"}}},"media_ids":["609741"],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"126571","name":"go-PetitInstitute"},{"id":"2076","name":"NIH"},{"id":"181145","name":"NHLBI"},{"id":"7270","name":"atherosclerosis"},{"id":"667","name":"robotics"},{"id":"181146","name":"guidewire"},{"id":"175342","name":"go-medicalrobotics"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:jerry.grillo@ibb.gatech.edu\u0022\u003EJerry Grillo\u003C\/a\u003E\u003Cbr \/\u003E\r\nCommunications Officer II\u003Cbr \/\u003E\r\nParker H. Petit Institute for\u003Cbr \/\u003E\r\nBioengineering and Bioscience\u003C\/p\u003E\r\n","format":"limited_html"}],"email":["Jerry.grillo@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}