{"623772":{"#nid":"623772","#data":{"type":"event","title":"Diversity and Response in Immune Repertoires","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAleksandra Walczak, \u003C\/strong\u003E\u003Cstrong\u003EPh.D\u003C\/strong\u003E.\u003Cbr \/\u003E\r\nLaboratoire de Physique Th\u0026eacute;orique\u003Cbr \/\u003E\r\nEcole Normale Sup\u0026eacute;rieure\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT\u003C\/strong\u003E\u003Cbr \/\u003E\r\nThe diversity of repertoires of B-cell and T-cell receptors is generated by a stochastic process of gene rearrangement called VDJ recombination, and is later sculpted by selection, clonal proliferation, and somatic hypermutations. I will show how these processes can be learned quantitatively from high-throughput repertoire sequencing data. The resulting models can then be used to estimate the diversity of repertoires and their overlap between individuals, to identify condition-specific immune receptors from patient cohort data, and to detect signatures of immune responses in single patients, opening the way for novel sequencing-based diagnostic\u003Cbr \/\u003E\r\nand prognostic tools.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBIOGRAPH\u003C\/strong\u003E\u003Cstrong\u003EY\u003C\/strong\u003E\u003Cbr \/\u003E\r\nAleksandra Walczak received her PhD in physics at the University of California San Diego. After a graduate fellowship at the Kavli Institute for Theoretical Physics (UCSB), she worked on applying information theory to signal processing in small gene regulatory networks at the Princeton Center for Theoretical Science. Currently based at the \u0026Eacute;cole Normale Sup\u0026eacute;rieure as a CNRS researcher, she studies the effects of selection on population genealogies, collective behaviour of bird flocks and statistical descriptions of the immune system. She was awarded the \u0026ldquo;Grand Prix Jacques Herbrand de l\u0026rsquo;Acad\u0026eacute;mie des sciences\u0026rdquo; in 2014 and the bronze medal of CNRS in 2016.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHost: Joshua Weitz, Ph.D.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A Biological Sciences Seminar by Aleksandra Walczak, Ph.D."}],"uid":"27964","created_gmt":"2019-07-29 19:18:40","changed_gmt":"2019-07-30 15:07:10","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-09-19T11:55:00-04:00","event_time_end":"2019-09-19T11:55:00-04:00","event_time_end_last":"2019-09-19T11:55:00-04:00","gmt_time_start":"2019-09-19 15:55:00","gmt_time_end":"2019-09-19 15:55:00","gmt_time_end_last":"2019-09-19 15:55:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"623771":{"id":"623771","type":"image","title":"Aleksandra Walczak","body":null,"created":"1564427507","gmt_created":"2019-07-29 19:11:47","changed":"1564427507","gmt_changed":"2019-07-29 19:11:47","alt":"","file":{"fid":"237582","name":"Aleksandra-Walczack.jpg","image_path":"\/sites\/default\/files\/images\/Aleksandra-Walczack.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Aleksandra-Walczack.jpg","mime":"image\/jpeg","size":115787,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Aleksandra-Walczack.jpg?itok=X01cq3yZ"}}},"media_ids":["623771"],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"11599","name":"Joshua Weitz"},{"id":"166892","name":"School of Biological Sciences Seminar"},{"id":"181829","name":"Aleksandra Walczak"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}