{"626325":{"#nid":"626325","#data":{"type":"event","title":"Cytoskeletal Regulators in Health and Disease","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAikaterini Kontrogianni-Konstantopoulos, Ph.D.\u003Cbr \/\u003E\r\nDepartment of Biochemistry and Molecular Biology\u003Cbr \/\u003E\r\nUniversity of Maryland School of Medicine\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT\u003C\/strong\u003E\u003Cbr \/\u003E\r\nUsing the muscle and epithelial cells as model systems, my group has been studying the cytoskeleton as structural and signaling mediator in health and disease. This seminar will focus on the roles of two modular and multifaceted families of proteins the giant obscurins and their binding partner slow Myosin Binding Protein-C (sMyBP-C). Using complementary \u003Cem\u003Ein vitro\u003C\/em\u003E, \u003Cem\u003Eex vivo\u003C\/em\u003E and \u003Cem\u003Ein vivo \u003C\/em\u003Eapproaches, we show that obscurins and sMyBP-C play key roles in filament assembly and stabilization, Ca\u003Csup\u003E2+\u003C\/sup\u003E homeostasis, contractility, cell adhesion, and growth\/survival pathways. Consistent with their involvement in several cellular processes, mutations in the \u003Cem\u003EOBSCN\u003C\/em\u003E (encoding obscurins) and \u003Cem\u003EMYBPC1\u003C\/em\u003E (encoding sMyBP-C) genes have been causatively linked to severe and lethal diseases including skeletal and cardiac myopathies as well as cancer. We have therefore generated a number of disease models carrying truncated or mutant obscurins and sMyBP-C aiming to decipher the molecular and cellular alterations that lead to disease pathogenesis with the ultimate goal of designing new therapies in the form of rescue peptides and\/or CRISPR technology.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHost: Yuhong Fan\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A Biological Sciences Seminar by Aikaterini Kontrogianni-Konstantopoulos, Ph.D."}],"uid":"27964","created_gmt":"2019-09-17 22:08:10","changed_gmt":"2019-09-17 22:08:10","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-11-14T10:55:00-05:00","event_time_end":"2019-11-14T10:55:00-05:00","event_time_end_last":"2019-11-14T10:55:00-05:00","gmt_time_start":"2019-11-14 15:55:00","gmt_time_end":"2019-11-14 15:55:00","gmt_time_end_last":"2019-11-14 15:55:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"626323":{"id":"626323","type":"image","title":"Aikaterini Kontrogianni-Konstantopoulos, Ph.D.","body":null,"created":"1568757805","gmt_created":"2019-09-17 22:03:25","changed":"1568757805","gmt_changed":"2019-09-17 22:03:25","alt":"","file":{"fid":"238449","name":"Kontrogianni-Konstantopoulos_Aikaterini.jpg","image_path":"\/sites\/default\/files\/images\/Kontrogianni-Konstantopoulos_Aikaterini.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Kontrogianni-Konstantopoulos_Aikaterini.jpg","mime":"image\/jpeg","size":53759,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Kontrogianni-Konstantopoulos_Aikaterini.jpg?itok=8L6MRFNy"}}},"media_ids":["626323"],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"182375","name":"Aikaterini Kontrogianni-Konstantopoulos"},{"id":"166892","name":"School of Biological Sciences Seminar"},{"id":"9552","name":"Yuhong Fan"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}