{"626870":{"#nid":"626870","#data":{"type":"event","title":"No Country for Old Mammals: The Comparative Genomics of Mammalian Ageing and Human Longevity","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EA School of Biological Sciences Seminar by Arcadi Navarro, Universitat Pompeu Fabra Barcelona\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe rapid progress of medical and comparative genomics is affording new data that allow testing hypothesis related to senescence and aging, both within and across species.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERecently, we studied the effects of genetic variants associated with complex human diseases appearing at different periods in life\u0026nbsp;and made observations that fitted the Mutation Accumulation and the Antagonistic Pleiotropy theories of ageing. In particular, we observed higher risk allele frequencies and large effect sizes for late-onset diseases. We also detected a significant excess of early\u0026ndash;late antagonistically pleiotropic variants. Strikingly, these variants tend to be harbored by genes related to ageing across many species.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThese results prompted a set of comparative genomic studies, which\u0026nbsp;so far\u0026nbsp;we have focused on coding variation of primates and mammals and on maximum lifespan.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWe use two different approaches. First, we search for parallel amino acid mutations that co-occur with increases or reductions in longevity across the primate and\u0026nbsp;mammal lineages. Second, we study how changes in rates of protein evolution correlate with changes in longevity across phylogenies using phylogenetic generalized least squares.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBoth approaches help identify\u0026nbsp;genes and pathways related to aging and longevity. They also enable\u0026nbsp;better interpretation of human longevity data coming from GWAS.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A School of Biological Sciences Seminar by Arcadi Navarro, Universitat Pompeu Fabra Barcelona"}],"uid":"30678","created_gmt":"2019-09-30 15:17:47","changed_gmt":"2019-09-30 15:19:58","author":"A. Maureen Rouhi","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-10-24T11:55:00-04:00","event_time_end":"2019-10-24T13:00:00-04:00","event_time_end_last":"2019-10-24T13:00:00-04:00","gmt_time_start":"2019-10-24 15:55:00","gmt_time_end":"2019-10-24 17:00:00","gmt_time_end_last":"2019-10-24 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"626071":{"id":"626071","type":"image","title":"Arcadi Navarro","body":null,"created":"1568238842","gmt_created":"2019-09-11 21:54:02","changed":"1568238842","gmt_changed":"2019-09-11 21:54:02","alt":"","file":{"fid":"238349","name":"arcadi_navarro.jpg","image_path":"\/sites\/default\/files\/images\/arcadi_navarro.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/arcadi_navarro.jpg","mime":"image\/jpeg","size":7867,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/arcadi_navarro.jpg?itok=McYh7No-"}}},"media_ids":["626071"],"groups":[{"id":"1278","name":"College of Sciences"}],"categories":[],"keywords":[{"id":"182320","name":"Arcadi Navarro"},{"id":"10645","name":"Greg Gibson"},{"id":"182498","name":"longevity and ageing across species"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022http:\/\/greg.gibson@biology.gatech.edu\u0022\u003EGreg Gibson\u003C\/a\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}