{"631453":{"#nid":"631453","#data":{"type":"event","title":"Micro-Physiological Systems Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EHansang Cho, Ph.D.\u003Cbr \/\u003E\r\nAssistant Professor\u003Cbr \/\u003E\r\nDepartment of Mechanical Engineering\u003Cbr \/\u003E\r\nSungkyunkwan University \u0026amp; University of North Carolina at Charlotte\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026ldquo;3D Human Brain models in Microfluidics for the Study of Neurological Disorders\u0026rdquo;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWith hundreds of billions of neurons and thousands of trillions of synaptic connections between them, the human brain is the most complex system on earth. However, there are no well-developed human brain models to study the brain activities in either laboratory environments or in animal bodies. Here, I present micro-scaled 3D environments that reconstruct a 3D human brain in Alzheimer\u0026rsquo;s disease (AD) by recapitulating AD signature of elevated levels of amyloid-beta (A-beta), tau proteins, activation of microglia, immune cells resident in a central nervous system (CNS), and consequent neuronal damage. In particular, the model mirrored microglial neurotoxic activities such as axonal cleavage and neurotoxic release.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003ELunch will be provided at the beginning of the seminar.\u003C\/em\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u00223D Human Brain models in Microfluidics for the Study of Neurological Disorders\u0022 - Hansang Cho, Ph.D. - Sungkyunkwan University \u0026 UNC at Charlotte"}],"uid":"27349","created_gmt":"2020-01-22 19:08:29","changed_gmt":"2020-01-22 19:08:29","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-02-10T13:00:00-05:00","event_time_end":"2020-02-10T14:00:00-05:00","event_time_end_last":"2020-02-10T14:00:00-05:00","gmt_time_start":"2020-02-10 18:00:00","gmt_time_end":"2020-02-10 19:00:00","gmt_time_end_last":"2020-02-10 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/pwp.gatech.edu\/biomicrofluidics\/","title":"Seminar Website"},{"url":"https:\/\/nanoscalescience.uncc.edu\/directory\/hansang-cho-phd","title":"Cho profile"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"126571","name":"go-PetitInstitute"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:takayama@gatech.edu\u0022\u003EShuichi Takayama\u003C\/a\u003E, faculty host\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}