{"64163":{"#nid":"64163","#data":{"type":"event","title":"Stem Cell Engineering Center Seminar Series","body":[{"value":"\u003Cp\u003EAbstract: Microsystems have the potential to impact biology by providing\n new ways to manipulate cells and the microenvironment around them.\u0026nbsp; \nSimply physically manipulating cells or their environment\u2014using \nmicrofluidics, electric fields, or optical forces\u2014provides new ways to \norganize cell-cell interactions.\u0026nbsp; Our lab has been using cell \nmanipulation to study cell-cell interactions in stem cell self-renewal, \ndifferentiation, and nuclear reprogramming.\u0026nbsp; To control diffusible \nsignaling and study its influence on cell fate, we have developed arrays\n of microfluidic perfusion culture chambers that use fluid flow to \ncreate a convection-dominated transport environment.\u0026nbsp; This in turn \nprovides a more controlled soluble microenvironment in which to study \ndiffusible signaling in self-renewal and neural specification.\u0026nbsp; Using \nthese systems, we have identified the existence of previously unknown \nautocrine loops involved in fate specification, and have delineated the \neffects of shear itself on self-renewal.\u0026nbsp; We are also developed ways to \ncontrol cell-cell interactions by creating patterns of multiple \ndevelopmentally important cell types.\u0026nbsp; For example, by using \nmicropatterning to spatially arrange embryonic stem cells with respect \nto supporting cells found in the early blastocyst, we have been able to \nrecapitulate early developmental steps in vitro.\u0026nbsp; Together, the ability \nto control cell placement and diffusible signaling provide news ways to \nexploit stem cells\u2019 potential for both basic science and applied \nbiotechnology.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EStem Cell Engineering Seminar Series\u003C\/p\u003E\u003Cp\u003EJoel Voldman, PhD - Massachusetts Institute of Technology\u003C\/p\u003E\u003Cp\u003EMicroscale Manipulation of Cells and Their Environment for Controlling Stem Cell Fate\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Microscale Manipulation of Cells and Their Environment for Controlling Stem Cell Fate\u0022 - Joel Voldman, PhD - Massachusetts Institute of Technology"}],"uid":"27195","created_gmt":"2011-02-09 15:22:30","changed_gmt":"2016-10-08 01:54:05","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-03-10T10:00:00-05:00","event_time_end":"2011-03-10T11:00:00-05:00","event_time_end_last":"2011-03-10T11:00:00-05:00","gmt_time_start":"2011-03-10 15:00:00","gmt_time_end":"2011-03-10 16:00:00","gmt_time_end_last":"2011-03-10 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.rle.mit.edu\/rleonline\/People\/JoelVoldman.html","title":"Voldman Lab"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"167446","name":"SCEC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ETodd McDevitt - Director, Stem Cell Engineering Center\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}