{"64198":{"#nid":"64198","#data":{"type":"event","title":"Enhancing Solute Transport in Immature Cartilage and Engineered Tissue Constructs","body":[{"value":"\u003Cp\u003EAbstract:\u003C\/p\u003E\n\u003Cp\u003EOsteoarthritis (OA) is a debilitating degenerative disease that\nafflicts an estimated 27 million Americans age 25 and older. \u0026nbsp;This\ndisease leads to the progressive degradation of the articular layers of\ndiarthrodial joints, significantly compromising the main function of\ncartilage as a load bearing material, leading to pain and limiting\nactivities of daily living. \u0026nbsp;Cartilage functional tissue engineering is\na highly promising technology that aims to provide a biological\nreplacement to worn articular layers, as a modality that considerably\nexpands the limited options in the treatment of this disease. \u0026nbsp;Though\ncartilage degeneration is occasionally limited to small focal areas\nwithin articular layers, OA generally becomes symptomatic when\ndegradation has spread over much greater surface areas (such as greater\nthan 25 percent of the articular layer). Unfortunately, functional\ntissue engineering of large cartilage constructs is significantly\nconstrained by the balance of nutrient transport and\u003Cbr \/\u003E\nconsumption. \u0026nbsp;Several studies have shown that matrix deposition and\nelaboration of functional properties preferentially occurs near the\nperiphery of constructs, where nutrient supply from the surrounding\nculture medium is most abundant, whereas cells in the interior receive\nless nutrients and produce less matrix, with poorer functional\nproperties. In this presentation, we show that dynamic mechanical\nloading can enhance\u003Cbr \/\u003E\nsolute transport by up to an order of magnitude, and this enhancement\ncan be considerably accelerated by placing channels in the constructs.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioengineering Seminar Series\u003C\/p\u003E\u003Cp\u003EGerard Ateshian, PhD - Columbia University\u003C\/p\u003E\u003Cp\u003EEnhancing Solute Transport in Immature Cartilage and Engineered Tissue Constructs\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Gerard Ateshian, PhD - Columbia University"}],"uid":"27195","created_gmt":"2011-02-11 11:10:47","changed_gmt":"2016-10-08 01:54:05","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-03-08T10:00:00-05:00","event_time_end":"2011-03-08T11:00:00-05:00","event_time_end_last":"2011-03-08T11:00:00-05:00","gmt_time_start":"2011-03-08 15:00:00","gmt_time_end":"2011-03-08 16:00:00","gmt_time_end_last":"2011-03-08 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/bio7.mech.columbia.edu\/MBL\/","title":"Ateshian Musculoskeletal Biomechanics Lab"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host:\u0026nbsp; Bob Guldberg (404) 894-6589\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}